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Weighted models for insulin

This study investigates insulin-related gene expression across four distinct tissues: Islet, Adipose, Liver, and Gastroc. Utilizing a multiQTL model, we detect transcripts that correlate with insulin levels, with an enrichment analysis revealing significant associations. Specifically, we identify 1984 transcripts in islet tissue, 605 in adipose, 485 in liver, and 404 in gastroc, each associated with insulin modules across various chromosomes. This comprehensive analysis enhances our understanding of insulin dynamics and their genetic underpinnings across diverse tissues.

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Weighted models for insulin

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  1. Detected by scanone # transcripts that match weighted insulin model in each of 4 tissues: Weighted models for insulin Detected by Ping’s multiQTL model

  2. Histogram of transcript-to-insulin correlations

  3. Islet – enrichment for 1984 transcripts

  4. 17 Islet – modules 2 16 14 19 12 9 chromosomes Insulin trait

  5. Islet – enrichment for modules Insulin chromosomes

  6. Adipose – enrichment for 605 transcripts

  7. 19 Adipose – modules 2 9 14 17 12 chromosomes Insulin trait

  8. Adipose – enrichment for modules Insulin chromosomes

  9. Liver – enrichment for 485 transcripts

  10. Liver – modules 14 9 12 17 chromosomes Insulin trait

  11. Liver – enrichment for modules Insulin chromosomes

  12. Gastroc – enrichment for 404 transcripts

  13. 14 Gastroc – modules 2 12 16 19 17 9 chromosomes Insulin trait

  14. Gastroc – enrichment for modules Insulin chromosomes

  15. Insulin trait 4 tissues combined – modules Insulin

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