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Impact of siRNA Knockdown on Cyclin B1 Protein Levels and Kinase Activity in Breast Cancer Cell Lines

This study examines the effects of siRNA silencing on cyclin B1 protein levels and kinase activity in BT-474, MCF-7, SK-BR-3, and MDA-MB-231 breast cancer cell lines. Results show differential regulation of cyclin B1 expression and kinase activity post-siRNA treatment.

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Impact of siRNA Knockdown on Cyclin B1 Protein Levels and Kinase Activity in Breast Cancer Cell Lines

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  1. Fig. 1 BT-474 MCF-7 SK-BR-3 MDA-MB-231 A β-actin cyclin B1 C C C C Cdk1 siRNA1 siRNA1 siRNA1 siRNA1 siRNA3 siRNA3 siRNA3 siRNA3 siGFP siGFP siGFP siGFP BT-474 MDA-MB-231 MCF-7 SK-BR-3 1,6 cyclin B1 relative protein level 1,2 0,8 0,4 0 B 160 BT-474 C C C C siRNA1 120 siRNA1 siRNA1 siRNA3 siRNA1 siRNA3 siRNA3 siRNA3 siGFP siGFP siGFP siGFP relative kinase activity (%) 80 40 0 IgG C siGFP siRNA1

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