Utilizing NeSSI™ for Analytical Applications

1. Utilizing NeSSI™ for Analytical Applications Dave Veltkamp, CPAC New Sampling/Sensor Initiative (NeSSI™)

2. Overview of Talk • Describe the features of NeSSI™ most likely to impact lab applications • Discuss how NeSSI™ can facilitate laboratory applications and how current development fits lab needs • Outline some outside proposals recently written to help fund NeSSI™ development & demonstration • Mention some web-based resources at CPAC

3. What does NeSSI™ Provide • Simple “Lego-like” assembly • Easy to re-configure • No special tools or skills required • Standardized flow components • “Mix-and-match” compatibility between vendors • Growing list of components • Standardized electrical and communication (soon) • “Plug-and-play” integration of multiple devices • Simplified interface for programmatic I/O and control • Advanced analytics and measurement environment • Mini or Micro-analyzers • Integrated analysis or “smart” systems • Expose students to “Industrial” techniques & needs

4. P V NeSSI™: Enabler for MicroAnalytical (the “rail” concept) Standard “connectivity” Standard Electrical (Digital) Interface “Rail” SAM* Standard “hockey-puck PC” Anyone’s Actuator Anyone’s Sensor Standard Mechanical Interface “Rail” *Sensor/Actuator Manager

5. How Does NeSSI™ Fit in the Lab • Instrument/Sensor Interfaces • Design standards make development simpler • Reduced toolset to be mastered • Reduced sample variability to account for • Calibration/validation built-in • Consistent physical environment for measurement • Stream switching and/or mixing allow generation of standards to match analytical requirements • Reaction monitoring • Microreactors and continuous flow reactors • Batch reactors (with fast loop) • Sample Preparation • Gas handling (mixing, generation, delivery) • Liquid handling (mixing, dilution, conditioning, etc.)

6. Special Lab NeSSI™ Requirements • Flowing streams • Need to move liquid and gas streams through NeSSI™ • Most laboratory analysis involves discrete samples rather than sample streams • Analytical characterization of flow in NeSSI™ needed • Heating and Cooling • Laboratory applications need both • May require more rapid thermal response • Integration with other lab apparatus • Serial communication most common • Integration with lab software systems • Low cost • Competing with other solutions that don’t carry some of NeSSI’s more exotic features

7. Recent proposals featuring NeSSI™ • NSF Instrumentation for Materials Research (IMR) • Involves NeSSI™ and Microreactors to elucidate reaction kinetics and mechanisms for polymer modification chemistry • Builds on previous CPAC concepts for NeSSI™ as fluidic delivery AND analysis platform for microreactors • Includes development and testing of Synovec’s μ-MMS in NeSSI™ • 3 years, $718K

8. NeSSI™ Proposals (cont.) • NSF Chemistry Research Instrumentation and Facilities: Instrument Development (CRIF-ID) • Provides basic research and testing to characterize NeSSI™ flows and develop needed support sub-systems for utilizing NeSSI™ in laboratory applications • Funding to develop 3 (gas, liquid, and student lab) demonstration NeSSI™ systems • 3 years, $642K

9. NeSSI™ Proposals (cont.) • NSF Sensors and Sensor Networks • Involves using NeSSI™ as a platform for characterizing vapochromatic compounds and development of gas phase sensors • 2 identical NeSSI™ systems at UW and UM • 3 years, $612K • Washington Technology Center (WTC) • Development of prototype sensor/actuator manager (SAM) • Collaborative effort with Infometrix • Phase I, 6 months, $40K

10. NeSSI™ Fermentation System • Switching filter system to handle particulate laden liquid streams • Cells in fermentation broth • Supplied by Bob Sherman, Circor • Interested in plugging, cleaning, and other issues related to bio/pharma applications 2Filters

11. Circor FermI Filter System

12. Building Automated NeSSI™ • Swagelok provided 5 pneumatic valves, flow components and pressure transducers • Parker providing solenoid pilot valve manifold for actuating pneumatic valves • Brooks (Emerson) provided MFC’s and electronics • Honeywell providing funds for data I/O and control system • Thanks to all these contributions, we are very close to having an automated NeSSI™ system

13. Current CPAC NeSSI™ system

14. NeSSI™ Knowledge Network • Main topic page divided into 4 sections • News and Information • Discussion (NeSSI Q&A) • Component List • Only Manufacturers group may post here • Testing and Examples • Main NeSSI™ web site • http://www.cpac.washington.edu/NeSSI.htm • NKN can be found at • http://www.cpac.washington.edu/NeSSI/NKN.html

15. Component List Sub-topics • Page shown from the “Valve, Manual” topic • Listing of topics under manual valve main topic • Number of posts will correspond to different available components

16. Component List Page • Example post from the component list page • URL from Vendor • Spec. sheet or link • Picture, description, or link to more information • Other Vendors are currently working to populate the list with more components

17. Component List Page

18. User Self-Registration • Allows users to setup accounts • Selecting to join “Manufacturers” group will queue user’s registration until a moderator approves it. • Membership in other groups automatically approved immediately • Profile data will be used for NeSSI™ mailing list • Check the options available from the “Edit Profile” link once user activates account • Once user submits registration form, they are sent an email with instructions for activating their new account • Your account is not active till you log in and follow the instructions in the email

19. NKN Conclusion • New software and web site ready to be used • Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host NeSSI™ and NKN web sites • Site functions well on the new server – much easier to use for both posting and browsing • NeSSI Component List is becoming populated • Major manufacturers (Parker, Circor, Swagelok) already signed up and starting to supply content • Still need to get smaller suppliers to do the same • Need to get user community to register and start using it

20. NeSSI™ Sensor Survey • The purpose of this survey is to gather information on the sensors and actuators needed for NeSSI Sample Systems, Analytical Systems, and Cluster Applications.  • This data will be shared with sensor and instrument vendors to help them prioritize development of the devices needed across industries and applications.  • The more information you can provide, the faster better products and performance can be delivered

21. NeSSI™ Sensor Survey (cont.) • On-line survey form on the CPAC NeSSI™ web site • http://www.cpac.washington.edu/NeSSI/CPAC_NeSSI_Sensor_Survey.htm • Questions about condition sensors • Are you interested • How would you rank their importance • Operating ranges • Questions about analytical sensors • Are you interested • How would you rank their importance • Operating ranges • Questions about actuators • Questions about “Clusters” • Optional contact information

22. Sample Survey Questions

23. NeSSI™ Sensor Survey Results • Condition Sensors • Analytical Sensors

24. NeSSI™ Sensor Survey Results • Actuators • Clusters • 14 of the 21 respondents indicated they would share information with Vendors

25. NeSSI™ Sensor Survey (cont.) • Plan is to continue to solicit responses from users • Additions to survey questions or content welcome • May expand survey activities to help provide market directions to suppliers • Other aspects of NeSSI™ development • Applet Software and other issues relate to SAM • New opportunities or innovations • Need to reach beyond the normal NeSSI™ enthusiasts • Combined with the discussion board, surveys provide a valuable resource for both end-users and manufacturers of NeSSI

26. Summary & Conclusion • Automated NeSSI™ ready for development • Working spec/prototype design complete • Prototypes demonstrated in real applications • Resolution of the NeSSI™ bus issue • For some laboratory applications • Components and systems currently available will immediately work and provide benefits • For other applications • New components/architecture will be needed to “fit” current lab practices • The future holds a lot of promise!!