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DNA Mutations and Repair

DNA Mutations and Repair. Chapter 17. Detecting mutations with the AMES test. SUMMARY OF AMES TEST. AMES TEST. Saccharin Aflatoxin. 2-aminofluorene. Aflatoxin B1. DNA Repair: general characteristics. Double stranded DNA Redundancy of pathways. Types of DNA repair. Mismatch repair

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DNA Mutations and Repair

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  1. DNA Mutations and Repair Chapter 17

  2. Detecting mutations with the AMES test

  3. SUMMARY OF AMES TEST

  4. AMES TEST • Saccharin • Aflatoxin 2-aminofluorene

  5. Aflatoxin B1

  6. DNA Repair: general characteristics • Double stranded DNA • Redundancy of pathways

  7. Types of DNA repair • Mismatch repair • Direct Repair • Base-Excision Repair • Nucleotide Excision Repair

  8. Mismatch repair • Mut H • Recognize GATC hemi-methylation • Mut S • Mut L

  9. A closer look at mismatch repair

  10. DIRECT REVERSAL REPAIR Direct Repair

  11. BASE EXCISION REPAIR

  12. BASE EXCISION REPAIR

  13. Nucleotide Excision Repair

  14. Diseases of DNA repair!

  15. Xeroderma pigmentosum Autosomal recessive

  16. Hereditary Non-Polyposis Colon Cancer • HNPCC • 15% of all colon cancers

  17. Li-Fraumeni • P-53 mutation

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