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Understanding Cell Cycle Regulation and Cancer Growth

Explore how the cell cycle is regulated by internal and external factors, including cyclin, growth factors, and apoptosis. Learn about cancer cells' uncontrolled growth due to defects in regulatory genes like p53.

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Understanding Cell Cycle Regulation and Cancer Growth

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  1. 10.3 Regulating the Cell Cycle p286

  2. Q: How is the cell cycle regulated? • A: The cell cycle is controlled by regulatory proteins both inside & outside the cell.

  3. Regulatory Proteins • Internal regulators • External regulators • Cyclin-regulates the timing of the cell cycle. • Normally, when cells touch, they stop growing. • Growth factors-one of a group of external regulatory proteins that stimulate the growth and division of cells.

  4. Apoptosis-Process of programmed cell death.

  5. Cancer: Uncontrolled Cell Growth p53 gene • Q: How do cancer cells differ from other cells? • A: Cancer cells do not respond to the signals that regulate the growth of most cells. As a result, the cells divide uncontrollably.

  6. Cancer: Uncontrolled Cell Growth • Cancer-does not respond to the signals that regulate the growth of most cells. • Tumor-mass of cancer cells. • Caused by defects in the genes that regulate cell growth & division (p53 gene).

  7. WB p150-152 • Skip #9, 10, 12, 14

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