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Causes of Death in Deceased Organ Donors: Changing Profiles?

Causes of Death in Deceased Organ Donors: Changing Profiles?. G. Kirste, F. Schaub , CL Fischer-Fröhlich; Germany. ISODP 2011, Buenos Aires, Argentina. Causes of Death of Organ Donors. 82 % Atraumatic causes of death. Killed in road traffic. 2010: 3657 Verkehrstote.

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Causes of Death in Deceased Organ Donors: Changing Profiles?

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  1. Causes of Death in Deceased Organ Donors: Changing Profiles? G. Kirste, F. Schaub , CL Fischer-Fröhlich; Germany ISODP 2011, Buenos Aires, Argentina

  2. Causes of Death of Organ Donors 82 % Atraumatic causes of death

  3. Killed in road traffic 2010: 3657 Verkehrstote

  4. Reduced mortality after stroke

  5. Age of Organ Donors in Germany

  6. Introduction: • Variation in mortality according to cause of death due to: • Epidemiological changes • Stroke units • New advanced treatment protocols for devastating cerebral lesions • Proper care of vasospasm after subarachnoid hemorrhage (SAH) •  Changes in the population of organ donors ?

  7. Methods: • All potential and eligible donors in Germany (2006-2010): • Cause of death according to cerebral lesion causing admission reviewed (e.g. SAH -> vasospasm related stroke = SAH) • Annual variation in cause of death analyzed (significance: p<0.05) • Potential Donors: 13.657 • Eligible Donors: 9.440 • Actual Donors: 6.355

  8. Results: Potential Donors (n=13657) p=0.056 p=0.002 p=0.086 ns ns ns p<0.04 Donor age: 47±20 yrs. 63±15 yrs. 54±14 yrs. 46±22 yrs. 61±14 yrs. 41±21 yrs. p<0.001 Hypoxia=cererbral hypxoia, ICB=intracerebral bleeding, SAH=subarachnoid haemorrhage, Ischemia=ischemic stroke, Trauma=head trauma, Other=includes primary brain tumour, meningitis etc

  9. Results: Eligible Donors (n=9440) p=0.0022 p=0.06 ns p=0.076 ns p=0.043 p<0.001 Donor age: 45±19 yrs. 61±15 yrs. 53±13 yrs. 44±21 yrs. 60±13 yrs. 40±19 yrs. p<0.001 Hypoxia=cererbral hypxoia, ICB=intracerebral bleeding, SAH=subarachnoid haemorrhage, Ischemia=ischemic stroke, Trauma=head trauma, Other=includes primary brain tumour, meningitis etc

  10. Results: Actual Donors (n=6355) p=0.0098 p=0.069 ns ns ns ns p<0.02 Donor age: 44±19 yrs. 61±14 yrs. 53±13 yrs. 44±21 yrs. 60±13 yrs. 39±21 yrs. p<0.001 Hypoxia=cererbral hypxoia, ICB=intracerebral bleeding, SAH=subarachnoid haemorrhage, Ischemia=ischemic stroke, Trauma=head trauma, Other=includes primary brain tumour, meningitis etc

  11. Summary: • Introducing new treatment protocols (stoke units) for particular cerebral lesions contributes to changes in donor populations. • Number of donors with SAH decreased significantly. • Number of cases with cerebral hypoxia increased.

  12. Thank you

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