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Prediction of interactions

Prediction of interactions. Gene fusion. Gene neighbours. human. X. X. X. X. X. X. X. drosophila. elegans. X. X. X. X. X. X. X. mouse. Gene co-ocurrence. 3. 2. 2. 2. 2. phylogenies. Proteína B. Proteína A. Profiles (phylogeny). Expand interactions :

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Prediction of interactions

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  1. Prediction of interactions

  2. Gene fusion

  3. Gene neighbours

  4. human X X X X X X X drosophila elegans X X X X X X X mouse Gene co-ocurrence 3 2 2 2 2

  5. phylogenies Proteína B Proteína A

  6. Profiles (phylogeny)

  7. Expand interactions: Using “interologs” DIP COG members

  8. Predicción basada en estructura

  9. Step 1: Building a grid for a molecule

  10. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel Surface and core regions CORE VOLUME

  11. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  12. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  13. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel Convolution function: Obtain the maximum C

  14. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel Convolution function by Fourier Transform

  15. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  16. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  17. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  18. U n i v e r s i t a t P o m p e u F a b r a Baldomero Oliva Miguel

  19. STRING use of database http://string.embl.de

  20. Gene fusion

  21. Gene neighborhood

  22. Gene co-expression

  23. Text Mining

  24. Gene co-ocurrence

  25. GRAPH

  26. GRAPH Depth 2

  27. Prediction of metabolic pathways

  28. A-B 4.2.1.2 1.1.1.37 Oxalo-acetato Malato Fumarato

  29. Pathway based in common substrates and products (except water)

  30. Applications in proteomics

  31. Reference Reference Test Test sample sample sample sample RNA RNA extraction extraction mRNA Reverse Reverse Cy5 Cy5 - - dCTP Cy3 Cy3 - - dCTP transcription transcription cDNA cDNA - - Cy3 Cy3 cDNA cDNA - - Cy5 Cy5 - cDNA or oligo microarray Dr. L. Sumoy (CRG)

  32. pH 7 4 tumor metastasis metastasis tumor Mw 68.8 7505 4511 8401 6405 8301 28.4 2303 5201 8204 2202 7202 8201 5203 21.7 7201 7109 7115 7004 16.8 5004 9.1 Dra. A. Sierra (IRO)

  33. Dr. D. Andreu (UPF)

  34. SPOTS

  35. Galectin Tubulin  5 HSP27 STRING database DIP database Predicción estructural Cathepsin D Prdx 4 ATP synthase Laminin R Glyoxalase Proteinas identificadas Proteinas propuestas

  36. Help to solve 2D page gels

  37. Apply on the graph

  38. Filtering by weight & isoelectric point

  39. LISTA DE CANDIDATOS

  40. Explaining biological processes

  41. Functional interest

  42. FUNCIONAL GROUP (GO cluster) A FUNCIONAL GROUP (GO cluster) B

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