Respiratory Physiology

1. Respiratory Physiology

2. heart

3. heart circuitry

4. heart circuitry tissues

5. lung heart circuitry tissues

6. lung heart circuitry tissues cell

8. STRUCTURE of respiratory system • Conducting zone • Respiratory zone

9. STRUCTURE of respiratory system • Conducting zone • (nose, larynx, trachea, • bronchi, bronchioles) • The walls conducting airways • contain smooth muscle • Sympathetic • Parasympathetic • 2 receptors • relaxation, dilatation of the airway

10. STRUCTURE of respiratory system • Conducting zone • Anatomic dead space • V of the conducting airways • Physiologic dead space • V of the lungs that does not • participapate in gas exchance

11. STRUCTURE of respiratory system • Conducting zone • Physiologic dead space (VD) • V of the lungs that does not • participapate in gas exchance • PaCO2 – PECO2 • VD = VT x ---------------- • PaCO2 • VT – tidal volume • PaCO2 – PCO2 of arterial blood • PECO2 – PCO2 of mixed expired air

12. STRUCTURE of respiratory system Respiratory zone Alveoli Lung ~ 300 x 106 alveoli

13. diaphragm inspiration expiration

14. inspiration – mm. intercosales externi

15. expiration – mm. intercosteles interni

16. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

17. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

18. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

19. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

20. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

21. inspiration – mm. intercosales externi expiration – mm. intercosteles interni

23. pleura parietalis diaphragm inspiration expiration

24. pleura visceralis diaphragm inspiration expiration

25. pleura parietalis transmural pressure pleura visceralis diaphragm inspiration expiration

26. pleura parietalis pleura visceralis transpulmonal pressure diaphragm inspiration expiration

27. pleura parietalis pleura visceralis intrapulmonal pressure diaphragm inspiration expiration

28. pleura parietalis transmural pressure pleura visceralis intrapulmonal pressure transpulmonal p. diaphragm inspiration expiration

30. pleura parietalis transpulmonal p. pleura visceralis diaphragm inspiration expiration

31. PNEUMOTHORAX pleura parietalis transmural p. pleura visceralis bránice - diaphragma inspirace expirace

32. alveoli pleura parietalis transmural p. pleura visceralis intrapulmonal pressure transpulmonal p. diaphragm inspiration expiration

37. ventilation V

38. Physiologic dead space Is the volume of air in the lungs that does not participate in gas exchance (i.e.e it is dead) Anatomic dead space – is the volume of conducting airways Functional dead space volume – which is made up of alveoli that do not participate in gas exchance (alveoli that are ventilated, but are not perfused by pulmonary capilary blood)

39. Physiologic dead space PaCO2 – PECO2 V D = VT x ----------------------- PaCO2 VD – physiologic dead space (mL) VT – tidal volume (mL) PaCO2 – PCO2 of arterial blood (mmHg) PECO2 - PCO2 of expered air (mmHg)

40. Physiologic dead space PaCO2 – PECO2 V D = VT x ----------------------- PaCO2 40 - 30 VD = 500 x -------------- 40 = 500 x 0.25 = 125

41. Alveolar ventilation VA = (VT – VD) x breasths/min VA - alveolar ventilation (mL/min) VT - tidal volume (mL) VD - physiologic dead space (mL/min)

42. Alveolar ventilation VA = (VT – VD) x breasths/min VA = (500 – 125) x 16 = 375 x 16 = 6000 mL/min

43. lung heart circuitry tissues cell

45. diffusion

47. perfusion