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Mucinous Tubular and Spindle Cell Carcinoma: Clinical Overview and Prognosis

This case review discusses a 51-year-old Caucasian male with a 17 x 16 x 12 cm kidney tumor, primarily necrotic with hemorrhagic areas. Immunohistochemical analysis shows positive reactions for AE1-AE3, EMA, and Vimentin, and negative for HMB45, S-100, CAM 5.2, and Actin S. Mucinous tubular and spindle cell carcinoma is highlighted, identified through ultrasonography. Characterized as low-grade, it has a favorable prognosis with rare metastasis. Differential diagnoses include papillary RCC, sarcomatoid RCC, and angiomyolipoma.

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Mucinous Tubular and Spindle Cell Carcinoma: Clinical Overview and Prognosis

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  1. Case 3

  2. Basic clinical data • 51-year-old Caucassian male • Tumor of the kidney 17 x 16 x 12 cm • Widely necrotic (80% of tumorous mass) • Vital part was grey with hemorrhagias on cut section

  3. ???

  4. Locust vs. Trixalis or Acrida

  5. Positive reactions AE1-AE3 EMA Vimentin Negative reactions HMB45 S-100 CAM 5.2 Actin S Immunohistochemistry

  6. Mucinous tubular and spindle cell carcinoma

  7. Synonyms • Loopoma • RCC with lower-nephron differentiation • Low grade collecting duct RCC • Spindle and cuboidal RCC • Low grade spindle cell RCC

  8. Mucinous tubular and spindle cell carcinoma • Age range 17-82 years • Females are affected more frequently • Usually disclosed by ultrasonographic examination for different reasons • Favourable prognosis- low-grade tumors • Only 2 metastatic cases in the world literature

  9. Mucinous tubular and spindle cell carcinoma • Differential diagnostics: Papillary RCC Sarcomatoid RCC Angiomyolipoma Metastasis of adenocarcinoma

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