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Case 3

Case 3. 30 year old woman Visiting friend from out of province. Found deceased in bed Some ethanol ingestion, but no drug use, reported evening prior History of hypertension, no medications. At autopsy: Cardiomegaly (550 grams) and left ventricular hypertrophy (2.0 cm)

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Case 3

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  1. Case 3 • 30 year old woman • Visiting friend from out of province. Found deceased in bed • Some ethanol ingestion, but no drug use, reported evening prior • History of hypertension, no medications

  2. At autopsy: • Cardiomegaly (550 grams) and left ventricular hypertrophy (2.0 cm) • Arteriolonephrosclerosis

  3. Case 4 • 6 year old boy • Presented to hospital with 2 hours of vomiting • Vtach and hypotension during investigations, cardiac arrest • One week history occasional headaches and two day history intermittent chest pain • No known medical or family history

  4. Chromogranin Synaptophysin S100 Inhibin

  5. Case 5 • 23 day old infant female • Presented with abnormal respirations and became unresponsive • Transported to IWK, never regained consciousness • Approximately 8 hours presentation to death • Normal pregnancy and delivery, previously healthy

  6. At autopsy: • Well nourished and normally developed • No injuries • Subarachnoid staining, vascular congestion and petechial hemorrhages, markedly friable parenchyma

  7. Neuropathology consultation: • Purulent exudate parieto-occipital region • Perivascular cuffing monocytes and neutrophils, focal endothelialitis • Gram positive cocci, not paired • Blood culture (post mortem): • Streptococcus agalactiae, no other growth

  8. Mother GBS positive on prenatal screening • No antibiotics given at delivery

  9. Case 6 • 32 year old woman • Witnessed sudden collapse • No known medical history

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