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Sarcolemmal Displacement

Sarcolemmal Displacement. Will Adams. Cardiac Myopathies. Dilated Cardiomyopathy. Physiological. medlib.med.utah.edu. Hypertrophy (concentric). medic.med.uth.tmc.edu. Individual Myocyte Geometry. H = 50nm. H = 50nm. R = 10µm. R = 16µm. L = 80µm. L = 80µm. H = 50nm. R = 10µm.

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Sarcolemmal Displacement

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  1. Sarcolemmal Displacement Will Adams Disease Biophysics Group Will Adams

  2. Cardiac Myopathies Dilated Cardiomyopathy Physiological medlib.med.utah.edu Hypertrophy (concentric) medic.med.uth.tmc.edu Disease Biophysics Group Will Adams

  3. Individual Myocyte Geometry H = 50nm H = 50nm R = 10µm R = 16µm L = 80µm L = 80µm H = 50nm R = 10µm L = 110µm Physiological Concentric Hypertrophy Dilated Cardiac Myopathy (eccentric hypertrophy) Disease Biophysics Group Will Adams

  4. Displacement • Why displacement? • Mechanical energy dissipated from internal viscosity will depend on displacement and velocity • Perhaps the pathological morphology of the heart is maladaptive not only on a macroscale (ejection fraction) but on a microscale (intracellular drag) Disease Biophysics Group Will Adams

  5. Longitudinal Displacement Stress Displacement Disease Biophysics Group Will Adams

  6. Longitudinal Displacement Disease Biophysics Group Will Adams

  7. Transverse Displacement Disease Biophysics Group Will Adams

  8. Results Critical Ejection Fraction Diastole Systole Hypertension Disease Biophysics Group Will Adams

  9. Directions • Maintain cytosolic volume conservation • Intregrate a t-tubule network into ABAQUS http://mednote.co.kr/ Disease Biophysics Group Will Adams

  10. Acknowledgements • Adrian Podpirka Disease Biophysics Group Will Adams

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