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Analysis of E-Cadherin, α-Catenin, β-Catenin, and Vimentin in MCF7 and T47D Breast Cancer Cells

This study investigates the expression levels of E-cadherin, α-E-catenin, β-catenin, and Vimentin in various breast cancer cell lines (MCF7 and T47D) under different conditions, including treatment with CAF18 and CAF8 conditioned media. The role of IL-6 in these cellular responses is also examined. Using Western blotting techniques, we analyze protein expressions alongside GAPDH as a loading control. This research aims to elucidate the molecular mechanisms underlying breast cancer progression and the epithelial-mesenchymal transition (EMT) processes influenced by tumor microenvironment factors.

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Analysis of E-Cadherin, α-Catenin, β-Catenin, and Vimentin in MCF7 and T47D Breast Cancer Cells

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  1. MCF7 T47D T47D MCF7 B Ctrl CAF18-CM CAF18-CM Ctrl Ctrl E-cadherin α-E-catenin β-catenin Vimentin GAPDH MCF7 C D CAF18-CM+Ab MCF7 T47D CAF8-CM+Ab CAF18-CM CAF8-CM+Ab Ctrl Ctrl Ctrl Ctrl CAF8-CM CAF18-CM CAF8-CM CAF8-CM NAF-CM CAF8-CM NAF-CM Ctrl Ctrl E-cadherin E-cadherin β-catenin β -catenin Vimentin Vimentin ER- GAPDH GAPDH CAF8-CM Ctrl MCF7 T47D Ctrl CAF8-CM T47D MCF7 T47D CAF18-CM+Ab A IL-6 IL-6 Ctrl E-cadherin α -E-catenin α-E-catenin β-catenin Vimentin GAPDH SupplementaryFigure 6

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