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Cost-Effectiveness of HPV Vaccination in Preventing Cervical Cancer

Explore the cost-effectiveness analysis of vaccinating young girls against HPV to prevent cervical cancer. Learn about the impact of HPV types 16 and 18, vaccination costs, screening tests, probabilities, and Markov models. Conclusion: Yes, it is cost-effective to vaccinate young girls against HPV for preventing cervical cancer.

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Cost-Effectiveness of HPV Vaccination in Preventing Cervical Cancer

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  1. CostEffectivenessAnalysis Is it costeffective to vaccinateyounggirlsagainst HPV to prevent cervical cancer?

  2. Background • Human Papilloma Virus (HPV) is the cause of 99% of all cases of Cervical Cancer. • Thereare more than 100 different types of HPV, not all of themarecarcinogenic. • In 2008 a vaccine against HPV types 16 and 18 wasintroduced in DK to all 12 yearoldgirls. • HPV types 16 and 18 are the cause of 70% of all cervical cancers.

  3. Screening • Womenbetween the age of 23 and 50 areinvited to participate in a screening test to detectpre-cancerouscells (early stages of cancer) every 3 years. • Womenagedbetween 51 and 65 areinvited to a screening test every 5 years.

  4. HPV Vaccine 3500 kr 34000 pers Cervical cancer 400 pers. Healthy Death 200 pers. Screening 500.000 pers. No vaccine Pre-cancer 4000 pers.

  5. Costs and no. of persons per year

  6. Probability of going from onestate to anotherwithout vaccine

  7. Probability of going from onestate to anotherwith the vaccine. 70% reduction of cases

  8. Markov Models • Comparison of 2 Markov models • One without vaccine • One with vaccine

  9. CostEffectiveness Ratio Cost new – Costexisting Effect new – Effectexisting (1325+3500) – 3826 = 3700 kr./QALY 39,18 – 38,91

  10. Conclusion • Is it costeffective to vaccinateyounggirlsagainst HPV to preventcervical cancer? Yes • Wegain 0,27 QALY’s at the cost of 999 kr

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