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Glecaprevir - Pibrentasvir in HCV GT 1 & Prior DAA Treatment MAGELLAN-1 (Part 1)

The MAGELLAN-1 study investigates the use of Glecaprevir-Pibrentasvir in patients with Hepatitis C Virus (HCV) genotype 1 who have prior direct-acting antiviral (DAA) treatment experience. The clinical trial observed varying treatment regimens over 12 to 24 weeks involving doses of Glecaprevir and Pibrentasvir, with or without ribavirin. This study, conducted by Poordad et al. and published in Hepatology, highlights baseline characteristics, treatment efficacy, and offers insights into managing HCV in complex patient populations.

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Glecaprevir - Pibrentasvir in HCV GT 1 & Prior DAA Treatment MAGELLAN-1 (Part 1)

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  1. Phase 2 Treatment-Experienced Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1) Source: PoordadF, et al. Hepatology. 2017;66:389-97.

  2. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Study Features Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  3. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Treatment Regimens 0 12 24 Week GT 1 n = 50 Glecaprevir: 200 mgPibreantasvir: 80 mg SVR12 n = 6 Glecaprevir: 300 mgPibreantasvir: 120 mg Ribavirin: 800 mg n = 22 SVR12 Glecaprevir: 200 mgPibreantasvir: 120 mg SVR12 n = 22 Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  4. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Baseline Characteristics GLE-PIB= glecaprevir-pibrentasvir; RBV = ribavirin; BMI = body mass index Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  5. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Baseline Characteristics GLE-PIB= glecaprevir-pibrentasvir Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  6. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Study Design 6/6 21/22 19/22 Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  7. Glecaprevir-Pibrentasvir in HCV GT 1 & Prior DAA TreatmentMAGELLAN-1 (Part 1): Conclusions Source: Poordad F, et al. Hepatology. 2017;66:389-97.

  8. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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