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Ozonoff Lab

Ozonoff Lab. Infant Sibling study Recurrence risk of autism Other developmental problems in high risk families Earliest signs of autism – what, when Decrease age of identification and referral to intervention MRI study of high risk infants. UC Davis – UCLA Infant Sibling Study.

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Ozonoff Lab

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  1. Ozonoff Lab • Infant Sibling study • Recurrence risk of autism • Other developmental problems in high risk families • Earliest signs of autism – what, when • Decrease age of identification and referral to intervention • MRI study of high risk infants

  2. UC Davis – UCLA Infant Sibling Study • Phase I, 2003 – 2008 • 223 siblings of children with autism • 124 siblings of children with typical development • Phase II, 2008 – 2013 • 225 siblings of children with autism • 75 siblings of children with typical development 6 mo 12 mo 18 mo 24 mo 36 mo 7 yrs

  3. Developmental Outcomes at 36 Months (UCD and UCLA)

  4. Recurrence Rates(Baby Siblings Research Consortium) • BSRC sample • 12 sites • 664 high risk siblings, 338 low risk siblings • Prevalence of ASD significantly elevated in high risk families • 18.7% of high-risk siblings developed ASD • Even higher recurrence rates in • Male infants (26%) • Multiplex families (32%) • Sex of proband not predictive Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  5. ASD Outcomes by Risk Group and Infant Gender Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  6. ASD Outcomes by Multiplex Status and Infant Gender Ozonoff et al. (2011). Recurrence risk for ASD: A Baby Siblings Research Consortium study. Pediatrics, 128(3), e1-e8.

  7. Other Major Findings • Signs evident by 12 months in about half of affected children • Most infants have a period of typical development, followed by a loss of social engagement

  8. Clinical Implications,Future Directions

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