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Characterization of DUX4 and Rhox Gene Clusters in Murine Models

This study investigates the genetic architecture and functional implications of various gene clusters, including Gm7235 and Gm5585, in mice. We focus on the DUX4 cluster and its triplicates, alongside the Rhox gene cluster, assessing their conservation, expression patterns, and potential roles in developmental processes. The implications of gene duplications, such as Obox and Cphx, are also explored, providing insights into evolutionary adaptions and the genetic basis of phenotypic diversity in mammals.

colin-chambers
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Characterization of DUX4 and Rhox Gene Clusters in Murine Models

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  1. Human Mouse Gm7235 Gm5585 Crxos1 Gain Obox cluster Leutx Nanognb Tprx1 LOC647589 Rax2 Shox Dprx Argfx Ventx Loss Msx3 Rhox Triplicate Rhox cluster Cphx duplicate & remnants Cphx Triplicate Repeat Dux, DUX4 cluster Dux, Duxbl Triplicate others others Conserve

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