Innovation, industry and the NHS

1. Innovation, industry and the NHS Andrew Owens R&D Director & Cardiac Surgeon, South Tees Hospitals NHS Foundation Trust Reader in Cardiac Surgery, Newcastle University

2. Opportunities What can industry offer NHS? What can NHS offer industry?

3. What is an NHS Trust?

4. Who we are… South Tees Hospitals NHS Foundation Trust has: Over 8,800 staff £535million turnover

5. Our services Cancer Community services Primary care Children Paediatric ITC Spinal injuries Cardiothoracic Neurosurgery Regional trauma centre (south) Super specialist care Secondary care Trauma SERVICES Cardio- vascular Enhanced secondary care Renal Plastics Neonatal Radiotherapy Specialist care Integrated district services

6. Who we are… The trust also provides community services community nursing, school nursing, health visiting, physiotherapy, occupational therapy ward-based nursing in seven community & primary care hospitals manage two primary care centres - Resolution Health Centre in North Ormesby and Marske Medical Centre

7. Who we are… Annual throughput: Emergency admissions 81,404 Inpatients 180,988 Outpatients 477,253 A&E cases 127,781

8. Opportunities for industry? • Patient throughput • ‘Customers’ • Research/product development • Budget • Small % efficiency improvements = £ huge • Real need for cost-saving innovations • Awareness of need to invest to save

9. Opportunities for NHS? • Same again • Cost saving innovations • Devices • Processes • Disposables • Research opportunities • Multiple benefits of research participation • Grant/royalty income

10. Translational research • In medicine in particular, governmental funders of research and pharmaceutical companies have spent vast amounts internationally on basic research and have seen that the return on the investment is significantly less than anticipated. • Translational research has come to be seen as the key missing component.

11. Translational research? • Bench to bedside (to bench) • Definition depends on who you ask

12. Wellcome Translational research ….helps turn early-stage innovations into new health products, advancing the innovation to the point where it becomes attractive for further development by the medical, pharmaceutical or biotechnology industries.

13. US National Cancer Institute …. transforms scientific discoveries arising from laboratory, clinical, or population studies into clinical applications to reduce cancer incidence, morbidity, and mortality.

14. Typical funding…

15. i4i aims: • To accelerate the development of new healthcare products for the 21st century • Funds translational research, extending between basic research and pre-clinical trials or health technology assessments • This part of the innovation process is an area of high technological and business risk, and the projects funded by i4i reflect this

16. Not just drugs… • Pulsed plasmachemical deposition of bactericidal surfaces • Existing links with Durham Uni • University driven initiative • Biophysical Sciences Institute • Multi-disciplinary • Cell biology • Chemistry, physics • Microbiology • Medicine • Industry

17. Did it tick funding boxes? • Clinical problem HCAI - £1000 million per annum • Between basic research and pre-clinical trial • Multidisciplinary, existing technology, industry links • High risk - may be completely cytotoxic

18. What I learnt • Physical scientists & industry bring a new perspective to medicine (and vice versa) • Potential projects are out there • Funding is available • Academic support is available • NHS support is available

19. Conclusions • NHS Director perspective • Opportunities for industry • Enormous numbers – patients, costs, consumables • Never ending demand • Huge need for efficiency savings • Can only be met through innovation • Need to engage NHS with industry and academia