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Skeletal Muscle Tissue Engineering

Skeletal Muscle Tissue Engineering. Doron Schwartz Pennsylvania State University BIOE 445 October 4, 2012. Skeletal Muscle Tissue. What is Skeletal Muscle? Types of Injuries Current Methods. This presentation focuses on three aspects of skeletal muscle tissue engineering .

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Skeletal Muscle Tissue Engineering

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  1. Skeletal Muscle Tissue Engineering Doron Schwartz Pennsylvania State University BIOE 445 October 4, 2012

  2. Skeletal Muscle Tissue • What is Skeletal Muscle? • Types of Injuries • Current Methods

  3. This presentation focuses on three aspects of skeletal muscle tissue engineering Vascularization Scaffolding Techniques Mechanical Properties

  4. Engineering vascularized skeletal muscle tissue PLLA/PLGA scaffold Myocyte differentiation - cocultured with myoblasts and endothelial cells Vessel-like network formation in vitro - added embryonic fibroblasts

  5. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering SEM micrographs of DegraPol®membranes Electrospinning: electric charge is used to draw fibers from a liquid

  6. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering

  7. Engineered skeletal muscle tissue networks with controllable architecture neonatal rat skeletal muscle tissue networks

  8. Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components Table 1. Surface properties of the different polypyrrole–dopant combinations for thin and thick films and impedance at two different frequencies for thick films.

  9. Excitability and isometric contractile properties of mammalian skeletal muscle constructs engineered in vitro laminin coated anchors adult rat myogenic precursor cells 1.2-ms pulse width, 40 V, for 2 s

  10. Mechanical stimulation improves tissue-engineered human skeletal muscle

  11. Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury Cells can tolerate strains of 65% for 1 h and 40% for ~3 h

  12. Vascularization, scaffolding, and mechanical properties are major components of skeletal muscle tissue engineering Questions?

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