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Bioinformatics Technology Group: Advancing Molecular Biomedicine Through Data Analysis

The Bioinformatics Technology Group at the Institute of Molecular and Cellular Biology focuses on managing and analyzing data generated from high-throughput molecular biology experiments. With expertise in microarray data, genome sequence analysis, and protein interactions, we assist researchers in navigating complex data challenges. Our services include expert advice on experimental design, data analysis support, development of custom analysis pipelines, and technical education in bioinformatics tools. We aim to empower molecular biology groups to leverage their data effectively in an increasingly data-rich scientific landscape.

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Bioinformatics Technology Group: Advancing Molecular Biomedicine Through Data Analysis

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  1. Institute of Molecular and Cellular Biology FACULTY OF BIOLOGICAL SCIENCES BHRC: bioinformatics technology group David R. Westhead (FBS)*, Andrew J. Bulpitt (Computing)

  2. Raison d’être • Molecular biomedicine is becoming increasingly data rich • DNA microarrays – measure expression of >25000 genes in one experiment and databases contain 1000s of experiments • New generation sequencing • My group is now dealing with experiments that produce almost a human genome of sequence in one run (3 Giga bases) • New proteomic methods e.g. SILAC • Molecular biology groups generate this data but seldom have the computer skills to handle it or the statistical skills to analyse it • The technology group will provide this service

  3. What sort of data? • We are used to being flexible and dealing with new data types • DRW group expertise • Microarray data • High-throughput sequencing – particularly Chip-seq, RNA seq and genomic sequence • Protein structure and interactions • AJB group expertise • Image analysis • But we will aim to be able to support other needs as well

  4. What sort of data/methods ? • Here is a more extensive list of what the group could do • Genome sequence analysis • Gene expression analysis using sequencing and array methods • ChIP on chip and ChIP-seq • Sequence motif discovery • Copy number analysis • Annotation - comparative and ab initio techniques • Gene network analysis • Point mutations and SNPs • Comparative genome studies • Genome wide association studies • Protein structure prediction • Analysis of protein microarrays • High throughput mass spectrometry data • Protein-Protein docking • Protein Interaction • Simulation of cellular subsystems to analyze pathways and regulatory/signalling networks • Tools for automated literature searches

  5. Consultancy • We will provide • Expert advice on experimental design and data analysis • Expert advice and support for the development of grant application proposals • Co-Investigator or researcher input into external grant activity • Education on bioinformatics tools and methods

  6. Technical support • We will provide • Support and provide expertise in using existing tools and software packages • Expertise in scripting languages to develop analysis pipelines • Expertise in high volume data analysis and statistics, including novel methods and bespoke analyses • Developing new interfaces for existing tools • Development of databases to store and host data • WWW developments

  7. Funding and access to the group • How will funding work • BHRC funds 2 posts for 5 years • You will be able to apply for access to this resource • Level of demand is not clear at the moment • Longer term we aim to make the group self funding from grant applications • You will include costs on your grant • Different levels of cost depending on the project and how much support is needed

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