1 / 7

BHRC: bioinformatics technology group

Institute of Molecular and Cellular Biology FACULTY OF BIOLOGICAL SCIENCES. BHRC: bioinformatics technology group . David R. Westhead (FBS)*, Andrew J. Bulpitt (Computing). Raison d’être. Molecular biomedicine is becoming increasingly data rich

deidra
Télécharger la présentation

BHRC: bioinformatics technology group

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Institute of Molecular and Cellular Biology FACULTY OF BIOLOGICAL SCIENCES BHRC: bioinformatics technology group David R. Westhead (FBS)*, Andrew J. Bulpitt (Computing)

  2. Raison d’être • Molecular biomedicine is becoming increasingly data rich • DNA microarrays – measure expression of >25000 genes in one experiment and databases contain 1000s of experiments • New generation sequencing • My group is now dealing with experiments that produce almost a human genome of sequence in one run (3 Giga bases) • New proteomic methods e.g. SILAC • Molecular biology groups generate this data but seldom have the computer skills to handle it or the statistical skills to analyse it • The technology group will provide this service

  3. What sort of data? • We are used to being flexible and dealing with new data types • DRW group expertise • Microarray data • High-throughput sequencing – particularly Chip-seq, RNA seq and genomic sequence • Protein structure and interactions • AJB group expertise • Image analysis • But we will aim to be able to support other needs as well

  4. What sort of data/methods ? • Here is a more extensive list of what the group could do • Genome sequence analysis • Gene expression analysis using sequencing and array methods • ChIP on chip and ChIP-seq • Sequence motif discovery • Copy number analysis • Annotation - comparative and ab initio techniques • Gene network analysis • Point mutations and SNPs • Comparative genome studies • Genome wide association studies • Protein structure prediction • Analysis of protein microarrays • High throughput mass spectrometry data • Protein-Protein docking • Protein Interaction • Simulation of cellular subsystems to analyze pathways and regulatory/signalling networks • Tools for automated literature searches

  5. Consultancy • We will provide • Expert advice on experimental design and data analysis • Expert advice and support for the development of grant application proposals • Co-Investigator or researcher input into external grant activity • Education on bioinformatics tools and methods

  6. Technical support • We will provide • Support and provide expertise in using existing tools and software packages • Expertise in scripting languages to develop analysis pipelines • Expertise in high volume data analysis and statistics, including novel methods and bespoke analyses • Developing new interfaces for existing tools • Development of databases to store and host data • WWW developments

  7. Funding and access to the group • How will funding work • BHRC funds 2 posts for 5 years • You will be able to apply for access to this resource • Level of demand is not clear at the moment • Longer term we aim to make the group self funding from grant applications • You will include costs on your grant • Different levels of cost depending on the project and how much support is needed

More Related