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Body composition and physical function in women with multiple sclerosis

This study investigates the relationship between physical activity and body composition on lower-limb physical function in women with multiple sclerosis (MS) compared to healthy controls. Participants were matched by age and body mass index, examining factors such as daily step counts, relative fat mass, and leg lean mass. Results showed that women with MS exhibited significantly poorer lower-limb function, emphasizing the importance of targeting body composition through interventions aimed at reducing fat mass and increasing lean mass and physical activity to enhance independence in daily living.

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Body composition and physical function in women with multiple sclerosis

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  1. Body composition and physical function in women with multiple sclerosis Christie L. Ward, MS; Yoojin Suh, MS; Abbi D. Lane, MS; Huimin Yan, MS; Sushant M. Ranadive, PhD; Bo Fernhall, PhD;Robert W. Motl, PhD; Ellen M. Evans, PhD

  2. Aim • Determine whether physical activity and body composition were differentially associated with lower-limb physical function in persons with multiple sclerosis (MS) compared with controls. • Relevance • Identifying elements most related to physical functioning for persons with MS may optimize lifestyle choices that prolong independence.

  3. Method • Participants: • Females with MS and controls. • Matched for age and body mass index. • Measures: • Physical activity: daily step counts. • Relative fat mass. • Leg lean mass: dual energy X-ray absorptiometry. • Lower-limb physical function: objective performance tests.

  4. Results • Persons with MS had 12.5% to 53% poorer lower-limb physical function than controls. • Physical activity, relative fat mass, and leg lean mass to body mass ratio associated with lower-limb physical function in both groups. • Median splits: Higher relative fat mass, lower leg lean mass to body mass ratio, and MS conferred poorer lower-limb physical function.

  5. Conclusion • Physical activity, relative fat mass, and leg lean mass to body mass ratio were associated with lower-limb physical function. • Results suggest targeting body composition for MS interventions. • Specifically: reducing adiposity, increasing lean mass, and/or increasing physical activity levels

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