Analysis of Ion Channel Structures and Interactions in Different Membrane Environments

Dec 03, 2025

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This study examines the structural characteristics and interactions of various ion channels, including KvAP, Ci-VSP, and NachBac, across different membrane compositions (DOPC and DOTAP). Figures illustrate the spatial relationships and distances between these channels, emphasizing their tetrameric formations and comparative dimensions. The analysis highlights the impact of membrane thickness on the stability and functionality of these ion channels, providing insights into their potential biological roles in cellular environments.

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Analysis of Ion Channel Structures and Interactions in Different Membrane Environments

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Mokrab & Sansom, Fig. 1 S1 S3 S2 * * * * Paddle loop S4 Linker A B
Mokrab & Sansom, Fig. 2 0 ns 30 ns 60 ns
Mokrab & Sansom, Fig. 3 Chimera NachBac MlotiK1 KvAP VS dPP (Å) Ci-VSP Hv1 y (Å) KcsA x (Å)
Mokrab & Sansom, Fig. 4 A B Tetramers in DOPC Tetramers in DOTAP DOPC DOTAP dZ (Å), upper dZ (Å), lower Thickness (Å)
Mokrab & Sansom, Fig. 5 A Ci-VSP KvAP VS Chimera Kv1.2 NachBac Mlotik1 Hv1 KcsA B C
Mokrab & Sansom, Fig. 6 A B
Mokrab & Sansom, Fig. 7 S1 S2 S3 S4 S5 S6 Chimera S1 S2 S3 S4 S5 S6 NachBac S1 S2 S3 S4 S5 S6 MlotiK1 S1 S2 S3 S4 S5 S6 KvAP VS S1 S2 S3 S4 Ci-VSP S1 S2 S3 S4 Hv1