1 / 12

The Role of Myc

Novus Biologicals. The Role of Myc. Rummukainen et al. Mod pathol 2001. A Master Regulator Gone Awry. How MYC was discovered. Pioneering work by Diana Sheiness and J. Michael Bishop from 1978 to 1979

garth
Télécharger la présentation

The Role of Myc

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Novus Biologicals The Role of Myc Rummukainen et al. Mod pathol 2001 A Master Regulator Gone Awry

  2. How MYC was discovered Pioneering work by Diana Sheiness and J. Michael Bishop from 1978 to 1979 First discovered that MC29, an avian carcinoma retrovirus does not contain the src gene(1978) Further study of MC29 led to the discovery of the c-myc oncogene (1979) Conserved among many species including Chicken, Cows, Mice, and Salmon Later on, the Myc family proteins were discovered (c-Myc, N-Myc, L-Myc, and also S and B-Myc) MC29V DNA From Sheiness et al. 1978

  3. Highly Regulated Expression • High mRNA turnover • Early Immediate Response • Gene • Extremely short half-life • Responds quickly to extracellular cues • Highly Conserved among different species • So…What could c-Myc be? Discovering The role of normal c-Myc

  4. C-Myc is a Transcription Factor Structural Elements Leucine Zipper Domain Helix-loop-helix Domain Max partner protein CACGTG E-box TRRAP (transactivation/ transformation association protein)

  5. C-Myc: A Transcriptional Activator

  6. C-Myc: A Transcriptional Repressor

  7. The Role of c-myc in Cancer

  8. How C-Myc Turns Oncogenic Paulsson et al. Leukemia 2003

  9. Effects of Oncogenic C-Myc are Pervasive in most Cancers Cell Cycle Deregulation Genomic Instability Angiogenesis Negative effects in Cell Growth, Size, and Differentiation (Proliferation) Langois et al. 2000

  10. The Apoptotis Paradox??? Normal Cells – Overexpression of Myc triggers Apoptosis Requires Max Induces release of cytochrome C Cyto C, APAF1, and Procaspase-9 form the Apoptosome ATP causes Caspase cascade which causes degradation of cell components Pelengaris et al, 2002

  11. Knockout Mice Give Insights Meyer et al. Nature Reviews Cancer 2008 • Myc-null is embryonic lethal • Eµ-Myc mice (useful transgenic mouse model) show Clonal B-cell Lymphoma

  12. The C-Myc Tree of Knowledge:How Myc has changed science Meyer et al. Nature Reviews Cancer 2008

More Related