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Effective Inhibition of AV Virus with Fluorescence Staining: A Study on Anti-Nucleoprotein Monoclonal Antibody Conjugate

This study investigates the treatment of AV virus through viral adsorption inhibition using a novel inhibitor. The process involves steps such as pretreatment and labeling with β-galactosidase for monitoring. Results show significant reduction in viral yield with various anti-nucleoprotein monoclonal antibodies conjugated with mouse IgG, paving the way for potential antiviral therapies.

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Effective Inhibition of AV Virus with Fluorescence Staining: A Study on Anti-Nucleoprotein Monoclonal Antibody Conjugate

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  1. A V Virus 1ｈ　 １h18 - 19h45mineach step Fluorescencestaining I Inhibitor Anti-nucleoprotein monoclonal Ab conjugated mouse IgG + MgCl2 Treatment Viral adsorption Ex336/Em490 Pretreatment β-galactosidase labeled anti-mouse IgG 4-Methylumbelliferyl galactoside Ｖ＋Ｉ Ｉ 4-Methylumbelliferyl products ＭＤＣＫ Oseltamivir carboxylate, mM B PVP-I, mg/ml MUーGAL MUーGAL Relative inhibition, % Relative virus yield, % MU MU A/Bel/42 A/WＳ/33 A/Aichi/2/68 A/PR/8/34 A/WSN/33 A/DK/HK/313/78 A/DK/HK/36/4 A/Memphis/1/71 A/DK/HK/677/1 A/DK/HK/313/78 A/USSR/92/77 A/DK/HK/23/76 A/Memphis/1/71 A/DK/HK/92/76 A/Texas/36/91 HumanAvianHumanAvianAvian Human Avian H1N1H3N2H5N3H9N2H3N2H5N3

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