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Cumulative Probability Analysis of Pneumococcal Etiology in Culture and Molecular Diagnostics

This study investigates the cumulative probability of pneumococcal etiology in clinical samples measured in CFU/ml and copies/ml using both culture techniques and lytA rtPCR methods. By analyzing log10 values and the distribution of non-pneumococcal (NP) counts, we aim to elucidate the prevalence of Streptococcus pneumoniae compared to other pathogens. The findings highlight the significance of molecular diagnostics in identifying pneumonia cases and improve understanding of microbial communities in respiratory infections.

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Cumulative Probability Analysis of Pneumococcal Etiology in Culture and Molecular Diagnostics

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  1. 10 8 6 4 2 0 log10 colonization cfu/ml (copies/ml) No SP No SP SP SP NP culture NP lytA rtPCR

  2. Cumulative probability of pneumococcal etiology % 50 40 30 20 10 0 0 1 2 3 4 5 6 7 8 log10 NP count

  3. %

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