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  1. A MCh+Rya MCh 110 90 70 Airway area (% initial area) 50 30 0 5 10 15 20 25 30 Time (min) B MCh ryanodine 2.5 2.0 F/F0 1.5 40 1.0 30 Ca2+ Oscillations (min-1) 20 10 0 0 100 200 300 400 Time (sec) C A B ECs 18 m SMC L D Point A: Point B: 50 mM K+ 50 mM K+ HBSS 4 Flash 4 HBSS Flash Flash Flash 3 3 F/F0 F/F0 2 2 1 1 0.0 1.0 3.0 4.0 5.0 0.0 1.0 3.0 4.0 5.0 Time (min) Time (min)