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Advances in Immunotherapy: Using Vaccines and Checkpoint Inhibitors for NSCLC Treatment

This comprehensive overview discusses the utilization of vaccines and immune checkpoint inhibitors in the treatment of non-small cell lung cancer (NSCLC). It covers vaccine strategies targeting tumor antigens and the outcomes of Phase 3 trials, focusing on various vaccine approaches. The document also details immune checkpoint blockade mechanisms, particularly involving CTLA-4 and PD-1/PD-L1 pathways, and evaluates criteria for assessing immune-related responses. Key clinical studies and current Phase 3 trials are summarized, providing insights into evolving therapeutic strategies for advanced NSCLC.

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Advances in Immunotherapy: Using Vaccines and Checkpoint Inhibitors for NSCLC Treatment

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Presentation Transcript

  1. Program Goals

  2. Introduction

  3. Using Vaccines in the Treatment of NSCLC

  4. Vaccine Approach in NSCLC Targeting Tumor Antigens

  5. Vaccines Evaluated in Phase 3 Lung Cancer TrialsStudy Designs

  6. Vaccines Evaluated in Phase 3 Lung Cancer Trials (cont)Study Designs

  7. Vaccines Evaluated in Phase 3 Lung Cancer TrialsStudy Results

  8. Vaccines Evaluated in Phase 3 Lung Cancer Trials (cont)Study Results

  9. Using Vaccines in the Treatment of NSCLC: Key Points

  10. Immune Checkpoints and Their Inhibition

  11. Immune Checkpoint Blockade Approach in NSCLCTargeting the Immune System

  12. CTLA-4: Upregulation and Blockade

  13. CTLA-4 in the Immune Response

  14. PD-1 and PD-L1 and PD-1/PD-L1 Blockade

  15. PD-1/PD-L1 in the Immune Response

  16. CTLA-4 and PD-1 Signaling Pathways

  17. Antibody Blockade of Immune Checkpoints

  18. Immune Checkpoints and Their Inhibition: Key Points

  19. Immune-related Response Criteria

  20. Evaluating Response to Immunotherapeutic Agents in Solid TumorsImmune-Related Response Criteria

  21. Defining Response WHO vs irRC

  22. Defining Response (cont) WHO vs irRC

  23. Patterns of Response to Cancer Immunotherapy

  24. Immune-related Response Criteria:Key Points

  25. Clinical Studies of Immune Checkpoint Inhibitor Therapy in Advanced NSCLC

  26. Ipilimumab + Chemotherapy in Advanced NSCLCDesign of Phase 2 Trial

  27. Ipilimumab + Chemotherapy in Advanced NSCLCResults

  28. Ipilimumab + ChemotherapyHistology Subgroup Analysis

  29. Anti-PD-1 and Anti-PD-L1 Monotherapy in Heavily Pretreated Patients With Advanced NSCLCEfficacy in Phase 1 Trials

  30. Anti-PD-1 and Anti-PD-L1 Monotherapy in Heavily Pretreated Patients With Advanced NSCLCSafety in Phase 1 Trials

  31. Anti-PD-1 and Anti-PD-L1 Monotherapy in Heavily Pretreated Patients With Advanced NSCLCSafety in Phase 1 Studies

  32. Phase 1 Study of Nivolumab in Heavily Pretreated Pts With Advanced NSCLCHistology Subgroup Analysis

  33. Phase 1 Studies of Single Agent Immunotherapies in First-Line Setting

  34. Combinations With Immunotherapy in Advanced NSCLC

  35. Combinations With Immunotherapy in Advanced NSCLC (cont)

  36. Clinical Studies of Immune Checkpoint Inhibitor Therapy in Advanced NSCLC: Key Points

  37. Tumor PD-L1 Level as a Biomarker for Response

  38. Relationship Between PD-L1 Tumor Status and Response to PD-1 and PD-L1 Inhibitors

  39. Relationship Between PD-L1 Tumor Status and Response to PD-1 and PD-L1 Inhibitors (cont)

  40. Other Immune Checkpoint Targets

  41. Some Other Immune Checkpoint Protein Targets

  42. Some Other Immune Checkpoint Protein Targets (cont)

  43. Ongoing Phase 3 Clinical Trials of Immune Checkpoint Inhibitor Therapy in Advanced NSCLC

  44. Some Ongoing Phase 3 Trials Second Line

  45. Some Ongoing Phase 3 Trials (cont) Second Line

  46. Some Ongoing Phase 3 TrialsFirst Line

  47. Program Summary

  48. Abbreviations

  49. Abbreviations (cont)

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