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This document reviews recent research and pooled safety data for MS treatments, including the efficacy of Teriflunomide, Alemtuzumab, and Fingolimod. It highlights adverse events associated with Alemtuzumab, particularly thyroid complications, and discusses vitamin D analogue Alfacalcidol for managing MS-related fatigue and thalamic atrophy. Key findings from studies including ADVANCE and STRATA are presented, examining disease worsening, relapse recovery, and factors influencing progressive disease risk. The impact of smoking on MS susceptibility and cognitive impairment in pediatric MS patients is also covered.
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