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Jan. 1987-Dec. 2006, n=89 M : F=58 : 31 Stage III : IV=38 : 51 Primary treatment

Overall survival according to initial treatment modality in locally advanced oral cancer(SqCC, Stage III/IV). Primary Op. RT. CCRT. Induction Chemo. P =.01. T stage 3,4. Primary Op. RT. CCRT. Induction Chemo. P >.05. Jan. 1987-Dec. 2006, n=89 M : F=58 : 31 Stage III : IV=38 : 51

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Jan. 1987-Dec. 2006, n=89 M : F=58 : 31 Stage III : IV=38 : 51 Primary treatment

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  1. Overall survival according to initial treatment modality in locally advanced oral cancer(SqCC, Stage III/IV) Primary Op. RT. CCRT. Induction Chemo. P=.01 T stage 3,4 Primary Op. RT. CCRT. Induction Chemo. P>.05 • Jan. 1987-Dec. 2006, n=89 • M : F=58 : 31 • Stage III : IV=38 : 51 • Primary treatment • Induction CTx. 38 • RT 13 • CCRT 7 • Op. 31 • No definitive survival gain in induction or CCRT group • organ preservation : 6 by induction and 3 by CCRT • Better survival was obtained in surgery after induction chemo than RT State 2008 , Frankfurt, Germany Kwang Hyun Kim, Seoul, Korea

  2. Role of Chemotherapy in Oral Cancer • The fact that surgery can incur severe functional problem according to the location renders organ preservation trial • Induction chemotherapy may induce a down staging of primary tumor in unresectable or marginally operable patient, allowing curative surgery and may improve survival • Induction chemotherapy could be used as a biomarker for the response to non-surgical treatment • CCRT from the beginning might exclude possibility of curative resection in non-responders State 2008 , Frankfurt, Germany Kwang Hyun Kim, Seoul, Korea

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