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Evaluating Airway Area and Calcium Oscillations in Response to MCh and FSK in Rat Models

This study investigates the effects of MCh and FSK on airway area and oscillatory calcium dynamics. Parameters measured include initial airway area percentages and fluorescent intensity over time, along with calcium oscillation frequencies. Key observations reveal the relationship between agonist concentration and physiological responses in airway tissues. The findings could contribute to understanding airway responsiveness and calcium signaling in bronchial smooth muscle cells, potentially informing therapeutic approaches for respiratory diseases.

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Evaluating Airway Area and Calcium Oscillations in Response to MCh and FSK in Rat Models

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  1. A MCh FSK IbTX 100 90 Airway area (% initial area) 80 0 5 10 15 Time (min) B MCh + FSK IbTX 100 80 Fluorescent intensiy 60 40 0 50 100 150 200 250 Time (sec) C MCh + FSK 10 IbTX 8 6 Ca2+ Oscillations (min-1) 4 2 0 0 50 100 150 200 250 Time (sec)

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