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3D Analysis of Normal Facial Variation: Data Repository and Genetics

3D Analysis of Normal Facial Variation: Data Repository and Genetics. Principal Investigators Seth M. Weinberg, PhD (U Pitt) Mary L. Marazita, PhD (U Pitt) Co-Investigators Michael Cunningham, MD, PhD (U Wash) Jacqueline Hecht, PhD (UT Houston) Karen T.Cuenco , PhD (U Pitt)

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3D Analysis of Normal Facial Variation: Data Repository and Genetics

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  1. 3D Analysis of Normal Facial Variation: Data Repository and Genetics • Principal Investigators • Seth M. Weinberg, PhD (U Pitt) • Mary L. Marazita, PhD (U Pitt) • Co-Investigators • Michael Cunningham, MD, PhD (U Wash) • Jacqueline Hecht, PhD (UT Houston) • Karen T.Cuenco, PhD (U Pitt) • Consultants • Chung How Kau, BDS, MScD, PhD (UA Birm)

  2. Aims Create a normative data repository containing3D facial surface images, facial measurements, GWA markers and demographic descriptors from 3500 individuals aged 5 – 40. Example of a 3D facial surface captured through stereophotogrammetry Utilize this data repository to identify genetic loci that influence quantitative variation in facial shape Using morphometric methods to visualize genotype-phenotype correlations

  3. Progress • IRB approval at all three sites (several rounds of modification) • Built infrastructure at coordinating center (Pitt) to receive data from collection sites • FaceBase Human Data Working Group documents and policies • CSOC approval • Tentative approval from NIDCR to begin recruitment • Revised NGA imminent

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