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Impact of ShcC Knockdown on ERK1/2 Activation in NH12 and YT-nu Neuroblastoma Cells

This study investigates the effects of ShcC knockdown on ERK1/2 activation in NH12 and YT-nu neuroblastoma cells. The research employs RNA interference to downregulate ShcC and examines the subsequent activation levels of ERK1/2. Notably, an elevation in activated ERK was observed in both NH12 and YT-nu cell lines post-knockdown. The analyses confirm that the involvement of ShcC is significant in regulating ERK1/2 signaling pathways in neuroblastoma cells, highlighting potential therapeutic targets for treatment.

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Impact of ShcC Knockdown on ERK1/2 Activation in NH12 and YT-nu Neuroblastoma Cells

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  1. Suppl. B NH-12 cells YT-nu cells ShcC RNAi Li C R1 R2 Li C R1 R2 ShcC P-Erk1/2 Erk1/2 a-tubulin Serum (-) for 24 h Effect of ShcC knockdown on ERK1/2 activation of NH12 and YT-nu neuroblastoma cells expressing ShcC. Activation of Erk was examined in the cells other than TNB-1 cells which expresses ShcC. In NH-12 cells and YT-nu cells, elevation in the levels of activated Erk was recognized following downregulation of ShcC.

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