Decoding Gene Prediction: Unraveling Human Genome Secrets

Chapter 6 Gene Prediction: Finding Genes in the Human Genome

Figure 6.1: Map of the human X-chromosome

Figure 6.2: Schematic view of a typical prokaryotic gene and the mRNA transcribed from the gene

Figure 6.3: Transcriptional units in prokaryotes (A) can contain multiple open reading frames; eukaryotic transcriptional units (B) can have only one ORF each

Figure 6.4: The eukaryotic promoter, defined by an assemblage of interacting protein transcription factors bound to DNA

Figure 6.5: A eukaryotic mRNA is processed by splicing after transcription to remove introns and join exons into a continuous coding sequence

Figure 6.6: Consensus promoter sequences based on a few strong E. coli promoters

Figure 6.7: The six possible reading frames within a short piece of double-stranded DNA

Figure 6.8: Output from NCBI’s ORF Finder program Courtesy of ORF/National Center for Biotechnology Information

Figure 6.T1: Promoter sequences recognized by some E. coli sigma factors

Figure 6.T2: One-letter code for ambiguous nucleotides

Figure 6.9: The splicing process and consensus sequences at the exon-intron boundaries and branch site

Figure 6.T3: Codon usage table for human genes

Decoding Gene Prediction: Unraveling Human Genome Secrets

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