nrendo.2014.185 pf1

Nov 19, 2014

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Figure 1 Opposing association between lower-body fat accumulation and metabolically healthy obesity. Karpe, F. & Pinnick, K. E. (2014) Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes Nat. Rev. Endocrinol. doi:10.1038/nrendo.2014.185.

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2014 biology
metabolically healthy obesity
figure 1 opposing association

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nrendo.2014.185 pf1

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Figure 1 Opposing association between lower-body fat accumulation and metabolically healthy obesity Karpe, F. & Pinnick, K. E. (2014) Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes Nat. Rev. Endocrinol. doi:10.1038/nrendo.2014.185

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Figure 1 Radiographic changes to melanoma metastases in the brain with administration of CTLA-4 blockade. Hodi FS et al . (2008) CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS Nat Clin Pract Oncol doi:10.1038/ncponc1183.

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nrendo.2010.147-pt4

Table 4 Effect of the del3-GHR polymorphism in children with growth hormone deficiency treated with rhGH. Alatzoglou, K. S. & Dattani, M. T. (2010) Genetic causes and treatment of isolated growth hormone deficiency—an update Nat. Rev. Endocrinol. doi:10.1038/nrendo.2010.147.

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nrendo.2013.227-pf2

Figure 2 Genotype frequencies for rs17817964 within and across ancestries based on the 1000 Genomes Project. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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nrendo.2010.146-pf1

Figure 1 World map indicating developing countries as classified by World Bank criteria in color and relating latitude by geographic regions to skin ability to synthesize vitamin D as estimated from information provided in an article by Tavera-Mendoza and White.

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Figure 1 Whole-body positron emission tomography scan showing a small glucose-avid lesion in the pelvis just superior to the bladder in the region of the left adnexa. Santillan A and Bristow RE (2006) Paraneoplastic cerebellar degeneration in a woman with ovarian cancer

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nrneph.2009.67-pf1

Figure 1 Renal survival of patients in our study with pauci-immune crescentic glomerulonephritis with and without ANCAs. Permission obtained from the American Society of Nephrology  Chen, M. et al. Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis.

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Figure 1 CT scan of tumor progression showing enlarged right laterocervical lymph nodes (white arrows) and laryngeal tumor (black arrows). Ares C and Allal AS (2005) Long-term complete remission of laryngeal Kaposi's sarcoma after palliative

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Figure 2 Schematic representation of potential depot-specific differences between subcutaneous and visceral adipose tissue in mice with normal GH signalling, low GH signalling (such as Ghr –/– mice) or increased GH signalling (such as GH transgenic mice).

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Figure 1 The products of two genes are required to reconstitute basic telomerase activity; the RNA component, hTR, which includes the template for synthesis of telomere DNA, and the protein catalytic component, hTERT, which has reverse transcriptase activity.

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nrendo.2012.140-pf5

Figure 5 Physiological role of GLP‑1 and proposed working models for the actions of short-acting and long-acting GLP‑1 receptor agonists in the postprandial state. Meier, J. J. (2012) GLP‑1 receptor agonists for individualized treatment of type 2 diabetes mellitus

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FIGURE 1 Localization of potential relevant molecular targets in irritable bowel syndrome with the specific classes of agents discussed in this Review. Cremonini F and Talley NJ (2005) Treatments targeting putative mechanisms in irritable bowel syndrome

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Figure 1 Postpartum contrast-enhanced helical chest CT scan showing an enlarged internal mammary lymph node (white arrow). Matthew S Katz et al . (2005) Palpable right breast mass in a pregnant woman . Nat Clin Pract Oncol 2 : 218 – 221 10.1038/ncponc0135.

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Figure 1 Minor salivary gland biopsy, stained with hematoxylin-eosin, from a patient with Sj ö gren's syndrome. Nordmark G et al. (2006) Mechanisms of Disease: primary Sj ö gren's syndrome and the type I interferon system Nat Clin Pract Rheumatol 2: 26 2 – 269 doi:10.1038/ ncprheum0173.

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Figure 1 Combination treatment schema for patients with rectal cancer enrolled in a clinical trial. Willett CG et al . (2007) Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer Nat Clin Pract Oncol 4 : 316 –321 doi:10.1038/ncponc0813.

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Figure 1 Results of cardiac function tests in the phase III trial of lapatinib plus capecitabine for metastatic breast cancer. Permission obtained from Geyer CE et al . (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733–2743.

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Figure 1 Schematic of oncolytic virotherapy mechanism of action: viral replication, cell killing, virus release and spread within cancer tissue but not normal tissues.

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Figure 1 Images of the case patient with an interstitial deletion of 5q22 encompassing the APC (adenomatous polyposis coli) gene, taken at 22 years of age. Heald B et al. (2007) Familial adenomatous polyposis in a patient with unexplained mental retardation

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Figure 1 The principal source of renal dopamine is circulating L -DOPA, which is freely filtered by the glomerulus.

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nrendo.2009.129 pf1

Figure 1 Statistical power of the DIAGRAM meta-analysis ( n = 9,562) to detect diabetes-related variants of different ORs across various risk allele frequencies, assuming complete coverage.

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Figure 1 Infection with JC virus is at first asymptomatic and presumably occurs at an early age by oral route. Calabrese, L. H. et al. (2014) Sorting out the risks in progressive multifocal leukoencephalopathy Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.167.

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nrneurol.2014.178 pf1

Figure 1 Upstream determinants (genes and molecular pathology) and downstream effects (clinical phenotypes) for the main neurodegenerative disorders. Pievani, M. et al. (2014) Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

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nrendo.2013.246 pf2

Figure 2 Transversal CT image of a typical small-bowel neuroendocrine tumour mesenteric metastasis (arrow). van Essen, M. et al. (2013) Neuroendocrine tumours: the role of imaging for diagnosis and therapy Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.246.

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