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Fold Increase

A. p-PKB. p-GSK3. **. -. -. -. -. **. *. +. +. +. +. **. L. 1.5. 1.5. -. -. -. -. +. +. +. +. **. **. LY. Fold Increase. 1.0. 1.0. p-PKB. Fold Increase. 0.5. 0.5. p-GSK3. 0.0. 0.0. C. LY. L. L+LY. C. LY. L. L+LY. Total PKB. Treatment. Treatment. I.

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Fold Increase

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  1. A p-PKB p-GSK3 ** - - - - ** * + + + + ** L 1.5 1.5 - - - - + + + + ** ** LY Fold Increase 1.0 1.0 p-PKB Fold Increase 0.5 0.5 p-GSK3 0.0 0.0 C LY L L+LY C LY L L+LY Total PKB Treatment Treatment I p-GSK3 p-PKB * LY * ** ** 2 p-PKB 2 ** Fold Increase ** Fold Increase p-GSK3 1 1 Total PKB 0 0 Treatment Treatment - - + + L B - - + + LY p-MAPK * C C C LY LY LY I I I I+LY I+LY I+LY p-MAPK ** p-MAPK ** 2 ** 1.5 * * Total PKB Fold Increase Fold Increase 1 1.0 I 0.5 - - 0 LY + + - - p-MAPK 0.0 + + C LY L L+LY Treatment Total PKB Treatment

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