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Project UPLIFT: Enhancing Well-being for People with Epilepsy through Mindfulness Practices

Project UPLIFT aimed to increase favorable thoughts and reduce depressive symptoms in individuals with epilepsy by delivering Mindfulness-Based Cognitive Therapy (MBCT) via web and telephone groups. Participants were assigned to groups, provided with necessary tech support, and engaged in 8 sessions focusing on self-compassion and coping strategies. Results showed significant improvement in depression compared to the waitlist group, demonstrating the effectiveness of both phone and web interventions. The study highlights the importance of addressing mental health alongside medical conditions.

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Project UPLIFT: Enhancing Well-being for People with Epilepsy through Mindfulness Practices

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  1. Project UPLIFT Main Outcome Results November 6, 2009 Nancy J. Thompson, Ph.D., M.P.H.

  2. Using Practice and Learning to Increase Favorable Thoughts

  3. Project UPLIFT • Delivery of MBCT by Web and Telephone Groups • To people with epilepsy • Randomly assigned to groups of 7 • Computers and Internet access provided if needed • Groups used for support surrounding Epilepsy • 8 Sessions • Facilitators • Peers and Graduate Students • Supervised by a licensed psychologist • Funding: Centers for Disease Control and Prevention

  4. The 8 Sessions

  5. Each Session • Check-in • Teaching • Group Exercise • Discussion • Skill-building w/ discussion • Review & Homework

  6. Design • Emphasis on Feasibility and Acceptability • Cross-over Design to Explore Effectiveness Stratum 1:Pretest2 gp 8 wk phoneInterimFollow-up Stratum 2:Pretest2 gp8 wk Web InterimFollow-up Stratum 3: PretestInterim2 gp8 wk phone Follow-up Stratum 4: PretestInterim2 gp 8 wk Web Follow-up Baseline Week 8 Week 16

  7. Results

  8. Participation • Screened (n=98) • Excluded (n=34) • Eligible (n=53) • Assessments • Completed Baseline (n=48) • Completed Interim Survey (n=40) • Completed Third Survey (n=35) • Participated in at least one session • Phone Intervention Group (n=12) • Web Intervention Group (n=10) • Phone Waitlist Group (n=10) • Web Waitlist Group (n=10) • 40 (75.5%) participated and completed the assessment following their participation

  9. Data Analysis • Baseline Differences • Only mean Self Compassion was statistically significant (t = 3.00, df = 38, p = 0.005) • Intervention group (mean = 19.7) • Waitlist group (mean = 16.0) • Repeated Measures ANCOVA • Assess the change in scores over time in the intervention and the waitlist groups • Controlled all analyses for Self Compassion

  10. Depression Measures

  11. Depression: mBDI • Treatment vs. Waitlist • Foverall = 40.93, p=.0001 • Finteraction = 10.14, p=.003* • Phone vs. Web vs. Waitlist • Foverall = 40.11, p=.0001 • Finteraction = 4.99, p=.012*

  12. Depression: BDI • Treatment vs. Waitlist • Foverall = 42.22, p=.0001 • Finteraction = 11.99, p=.001*

  13. Depression: BDI By Intervention Type • Phone vs. Web vs. Waitlist • Foverall = 41.65, p=.0001 • Finteraction = 5.93, p=.006*

  14. Effect by Presence of MDD * < .05 1Time by Condition 2Time by Condition by MDD

  15. Maintenance of Effects * < .05

  16. Knowledge/Skills & Self-Efficacy

  17. Knowledge & Skills • Treatment vs. TAU Waitlist • Foverall = 8.97, p=.005 • Finteraction = 4.75, p=.036* • Phone vs. Web vs. Waitlist • Foverall = 9.67, p=.004 • Finteraction = 3.67, p=.036*

  18. Depression Coping Self-Efficacy • Treatment vs. Waitlist • Foverall = 6.89, p=.013 • Finteraction = 3.59, p=.066

  19. Quality of Life 1.05<p<.10

  20. Satisfaction with Life • Treatment vs. Waitlist • Foverall = 4.52, p=.040 • Finteraction = 3.03, p=.090

  21. Mental Health QOL • Treatment vs. Waitlist • Foverall = 16.07, p=.0001 • Finteraction = 0.12, p=.727 • Phone vs. Web vs. Waitlist • Foverall = 15.10, p=.0001 • Finteraction = 0.50, p=.609

  22. Physical Health QOL • Treatment vs. Waitlist • Foverall = 3.99, p=.053 • Finteraction = 0.50 , p=.486 • Phone vs. Web vs. Waitlist • Foverall = 3.83, p=.058 • Finteraction = 0.31, p=.737

  23. Summary • Effective in: • Reducing depressive symptoms and teaching knowledge and skills associated with reducing depression • Intervention group showed significant improvement compared to the waitlist • Equally effective for those with and without MDD • Reduction in depressive symptoms maintained • Approaching significance for Satisfaction with Life and Depression Coping Self-Efficacy • Delivery • Both phone and web were significantly more effective in reducing depression than waitlist condition

  24. Summary • QOL Findings consistent with the premises of mindfulness • that suffering is not something to turn away from or something in need of fixing, • that it is worthy of attention, • that through attention we can see the ways in which we attach thoughts to the suffering that exacerbate it, and • that letting go of these thoughts reduces suffering (Segal et al.)

  25. Going Forward • ~$1 million Challenge Grant • UPLIFT for Prevention • Participants in 4 states • Georgia • Michigan • Texas • Washington

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