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DIDARP Specific Aims

9 th Drug Abuse Research Symposium September 12, 2014 8:30 am – 4:30 pm Charles Drew University of Medicine and Science Keck Lecture Hall 1731 E. 120 th Street, Los Angeles, CA 90059 http://www.cdrewu.edu/research/DrugAddictionResearch.

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DIDARP Specific Aims

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  1. 9th Drug Abuse Research SymposiumSeptember 12, 20148:30 am – 4:30 pmCharles Drew University of Medicine and ScienceKeck Lecture Hall1731 E. 120th Street, Los Angeles, CA 90059http://www.cdrewu.edu/research/DrugAddictionResearch

  2. NIH R24DA017298 Diversity-promoting Institutions Drug Abuse Research Development Program (DIDARP) at Charles R. Drew University of Medicine & ScienceProgram Theme: “Metabolic Effects of Nicotine: It Matters”; Training Theme: “Research Teams of the Future”Originally funded September 2004Competitive renewal funded April 2014-5 yearsProgram officer: Vishnudutt Purohit, Ph.D.

  3. DIDARP Specific Aims • To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or R01 grants; • To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences; and • To continue to enhance the research infrastructure at CDU to support substance abuse research.

  4. DIDARP Theme • The theme of the training and education program is “Metabolic Effects of Nicotine: It Matters” • Incorporates expertise at CDU in both the basic and clinical aspects of substance abuse. • Lead to collaborations with UCLA, Western University, CSU-DH, CSU-SB, Cal-tech, UTEP

  5. DIDARP Student Involvement • Students rotating in basic science labs and on clinical projects • CSUDH-undergraduate/Master’s students • CSUDH-Bridges Program -El Camino College, Compton College • King-Drew Magnet High School • CDU medical students and MPH students

  6. Research Day Goals • Highlight substance abuse research at CDU and its affiliates • Exposure of student and trainee research on substance abuse • Expose potential trainees to potential substance abuse mentors • Bring together substance abuse researchers for future seminars and funding opportunities • Exposure of research on substance abuse at CDU to research and teaching faculty, physicians from the surrounding community including MLK-Ambulatory Care Clinic and health clinics, drug abuse counselors, medical students, allied health professionals, community based health organization leaders, and other health care professionals

  7. Research Day: Special Highlights • Live streaming to UTEP, CSU-SB, ETSU University of Houston and Chicago State University • Visits by NIH and TRDRP program officers • Website: http://www.cdrewu.edu/research/DrugAddictionResearch • Slides, biosketch and pictures available shortly • Talks available shortly • CME credit for Dr. Hurd’s Talk

  8. Research Day Highlights • CE process and evaluations • Maria Castro •  CME evaluations • Jeonathan Rodriguez • 8:45 – 9:00 am University Welcome • David M. Carlisle, MD, PhD • President and CEO, Charles R. Drew University

  9. KEYNOTE SPEAKER • 9:00 -10:00 The Vulnerable Brain: Insights into the Neurobiology of Addiction Disorders (CME event) • Yasmin Hurd, PhD

  10. Research Day Morning TalksPOLICY RESEARCH SUBSTANCE ABUSE and FUNDING OPPORTUNITIES • 10:00-10:25 am Understanding Medical Marijuana Laws: What is and is not considered in past and current state policies • Rosalie Pacula, PhD • 10:25-10:50 am The Prescription Opioid Epidemic: Viewpoint from LA Times Journalists • Lisa Girion and Scott Glover • 10:50 -11:00 am MORNING BREAK

  11. Research Day Morning TalksPOLICY RESEARCH SUBSTANCE ABUSE and FUNDING OPPORTUNITIES(2) • 11:00-11:25 am The Prescription Opioid Epidemic: Viewpoint from Orange County DA • District Attorney Tony Rackauckas • 11:25-11:55 am Menthol Tobacco Use in Priority Groups & TRDRP Funding Opportunities • Norval Hickman, PhD, MPH • 11:55-12:25 pm NIH/NIDA Research Funding Opportunities 101 • Albert Avila, PhD

  12. Research Day Morning TalksTOP STUDENT/TRAINEE ORAL PRESENTATIONS • 12:25-12:35 pm Nicotine plus a high-fat diet (HFD) increases oxidative stress and triggers cardiomyocyte (CM) apoptosis in male mice. • Isai Rea

  13. Lunch Break • 12:35-1:35 PM • No food or drinks in the auditorium • Give your ticket • Veggie sandwiches for those preferring • Audience will go to lunch in shifts with trainees first • Trainees and researchers can meet with Dr. Hurd, Avila and Hickman outside to the right of the auditorium • Those who didn’t register in advance, can get remaining tickets at morning break. If no tickets remain, can get food if still available

  14. STUDENT/TRAINEE ORAL PRESENTATIONS • 1:35-1:45 pm Effects of early methylphenidate exposure on cannabinoid-induced conditioned place preference in young adult male rats • Michelle J. Stone

  15. Afternoon SessionBASIC SCIENCE and POLICY PRESENTATIONS • 1:45-1:55 pm Involvement of intrinsic and extrinsic pathways in hepatocellular apoptosis induced by combined treatment with nicotine and a high-fat diet (HFD) • Amiya Sinha-Hikim, PhD • 1:55 -2:20 pm The changing landscape for drug policy reform in the United States: Washington, Colorado, and beyond • Laura Thomas, MPH, MPP • 2:20-2:40 pm Neurochemical Mechanisms of Tobacco Use: Learning from Animal Models (via videoconference) • Luis M Carcoba PhD

  16. BASIC SCIENCE RESEARCH • 2:40 -3:00 pm Functional brain imaging of risky decision-making in methamphetamine dependence • Milky Kohno, PhD • 3:00-3:10 pm AFTERNOON BREAK •  3:10-3:30 pm Ameliorating methamphetamine-induced cognitive impairment • Alicia Izquierdo, PhD • 3:30-3:45 pm Nicotine Plus a High-Fat Diet Leads to Abdominal Lipolysis with Resulting Hepatic and Muscle Steatosis and Is Blocked By the Alpha 7 Nicotinic Receptor. • Desean L. Lee, MS

  17. BASIC SCIENCE RESEARCH • 3:45-4:00 pm Menthol alone alters receptor number and assembly of neuronal nicotinic receptors • Brandon Henderson, PhD • 4:00 -4:15 pm Down regulated dopamine receptors following chronic drug exposures in mice that prefer alcohol* • Amira Brown, PhD

  18. CLOSING REMARKS • 4:15-4:30 pm • PRESENTATION OF PRIZE FOR TOP STUDENT PRESENTATION AND POST-CONFERENCE EVALUATIONSTheodore Friedman, MD, PhD • 4:30 pm ADJOURN

  19. Instructions to Speakers • Please adhere to your time limits • We will give you 5 and 1 minute warnings • Please speak into the microphone • Allow time for questions • Repeat the question

  20. Instructions to Audience • Return promptly to your seat after breaks • Silence your cell phone • If on webex on your computer, turn off microphone

  21. Instructions to Speakers • MICROPHONE #1 - The lapel or lavalier wireless microphone will need to be clipped to your clothing and is best when placed on a shirt lapel or tie (for men) or a neckline (for women) that is just below the neck and mid-chest (chest-pocket level). The microphone is attached to a small box that fits into either a shirt pocket (for men) or a pants pocket (for men or women) or clips to the hemline of a skirt or pants (for men or women). • MICROPHONE #2 (X2) - The handheld wireless microphone is the standard size and shape and should be held near your mouth (between 6” to 12” is usually recommended) at all times during your presentation.

  22. Web and Podcasts • Web streaming and podcast (MP4) should be available, check out the home page at http://www.cdrewu.edu/research/DrugAddictionResearchto download. • Please make sure we have your email

  23. Evaluations Pacific Southwest Addiction Technology Transfer Center Survey • Pre-conference evaluations (green) • Post-conference evaluations (blue) • Turn in completed forms at registration table CDU CME-turn in questions and evaluations at the registration table

  24. Yasmin Hurd, PhD • Albert Avila, PhD • Norval Hickman, PhD • NIDA • DIDARP Advisory Committee • Darlene Parker-Kelly, Jabbar Hart, Dennis Curtis (AV) • Jeonathan Rodriguez, Annika Gill, Ron Edelstein-CME team

  25. Student/Staff helpers-Petra Duran, Beverly Jackson, Adaku Ume, Maria Diaz-Romero, Jocqui Johnson, Lupe Navarro • Beth Rutkowski, Maria Castro, Tom Freese, UCLA Integrated Substance Abuse Programs/ Pacific Southwest Addiction Technology Transfer Center • AXIS AXIS-Accelerating Excellence in Translational Science-National Institute on Minority Health and Health Disparities- U54MD007598 • UCLA CTSI grant-UL1TR000124 • NAPAFASA

  26. Substance Abuse Research at Charles Drew University For more information about substance abuse research and student opportunities at CDU, contact Dr. Friedman at 310-668-5197 or theodorefriedman@cdrewu.edu

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