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Impact of Probe Number on Chimpanzee Gene Expression Scores Across Various Tissues

This study investigates how the number of probes affects gene expression scores in chimpanzees, focusing on median interquartile ranges (IQRs) across different tissues. Data from 1H_1C probes are analyzed, with comparisons made between actual expression scores and simulated data generated by random sampling. The relationships are modeled quadratically, with results shown separately for datasets with different probe counts due to variations in algorithm processing. Significance is assessed through r² values and P-values. Findings contribute to understanding gene expression variability in chimpanzees.

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Impact of Probe Number on Chimpanzee Gene Expression Scores Across Various Tissues

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  1. Additional File 2. Effects of probe number on the variation of chimpanzee gene expression scores. Median interquartile ranges (IQRs) of expression scores (Y-axes) for the indicated tissue from all chimpanzees are plotted in red relative to the number of 1H_1C probes remaining in a probe set (X-axes). Median IQRs are plotted in black for simulated data wherein different numbers of probes were randomly sampled from 1H_1C_11 probe sets (see text for details). Note that only probe sets expressed in a given tissue are considered in this analysis (see Methods). Data from even (Panels A, C, E, G, and I) and odd numbers of remaining probes (Panels B, D, F, H, and J) in probe sets are presented separately due to differences in the way the RMA median polish algorithm processes them. Red and black curves represent predictions of fitted quadratic models for the actual and simulated data, respectively. The tissue from which the data was collected is indicated in each panel. r2 and P values respectively indicate the percent of variation explained by the quadratic model and the probability that the true relationship is quadratic for the actual data set.

  2. 0.35 0.35 0.35 0.35 0.35 0.30 0.30 0.30 0.30 0.30 0.25 0.25 0.25 0.25 0.25 0.20 0.20 0.20 0.20 0.20 0.15 0.15 0.15 0.15 0.15 brain brain median IQR heart heart median IQR kidney kidney median IQR liver liver median IQR testes testes median IQR 2 4 6 8 10 2 4 6 8 10 number of probes number of probes

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