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$1k Genome

$1k Genome. Presentation by Kyle Bolton. Why?. Would be nice to understand “human genomic diversity, encompassing all types of variation beyond common single-nucleotide variants.” (1) “mapping full genomes, scientists argue, is the key to individualized genetic information” (2) .

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$1k Genome

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  1. $1k Genome Presentation by Kyle Bolton

  2. Why? • Would be nice to understand “human genomic diversity, encompassing all types of variation beyond common single-nucleotide variants.”(1) • “mapping full genomes, scientists argue, is the key to individualized genetic information”(2)

  3. As of march 2010(2) • Knome $99,000 for whole genome • Illumina,Inc. announced sequencer that takes 1 week and $10,000per genome • HelicoseBioSciences mapped scientist Stephen Quake’s genome for $50,000. • Other players include • Applied Biosystems • 454 Life Sciences (a Roche company) • Complete Genomics • Pacific Biosciences • Ion Torrent Systems • Has a pH chip that can sequence “hundreds of millions of base pairs for $500”

  4. As of August 2010(3) • “ABI's SOLiD 4 platform has been said to generate a $6,000 genome, and the SOLiD 4 hq upgrade is planned for this fall with a target of delivering a $3,000 genome, Robison says” • Illumina’s ”HiSeq is supposedly at a $10,000 genome already” • “IonTorrent may only be two years away” • Complete Genomics • Life Technologies

  5. Factors for winner • Not necessarily the first product who’s materials cost is <=$1k • Accuracy • Equipment Cost • Maintenance • Training Required (foolproofing, even) • If inflation increases fast enough, and the cost lowers slow enough, it may prevent the cost from ever reaching $1k.

  6. Potential for (ab)use • Insurance companies • Employers • Criminal Justice Systems • Info Brokers • Medical Professionals • Drug Companies

  7. Sources • 1 “Anticipating the $1,000 genome” by Elaine R Mardis. doi: 10.1186/gb-2006-7-7-112. • 2 “Pacific BioScience Has A $1000 Genome Test That Could Save Your Life -- and the Industry” By Rachel Lehmann-Haupt. Pulbished on http://www.bnet.com/blog/healthcare/, March 4, 2010. • 3 “The 'Arbimagical' Goal of the $1,000 Genome” editorial? Published on http://www.genomeweb.com/blog, August 30, 2010

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