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Endocrinology

Endocrinology

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Endocrinology

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  1. Endocrinology MUDr. Ing. Mgr. Peter Celec, PhD. MPH petercelec@gmail.com www.imbm.sk

  2. Basics • E-mail communication • Time – alternatives • Literature sources – CVTI • Endocrine journal club – 2x • Test & Examination

  3. Syllabus • Principles • Hypothalamus & pituitarygland • Thyroidgland • Parathyroidgland • Pancreas • Diabetes mellitus • Adrenalgland • Gonads • Otherendocrinetissues (CVS, GIT, kidney)

  4. Principles

  5. Forms of communication

  6. Functions of hormones • Development & growth • Differentiation & reproduction • Homeostasis & immunity • Metabolism & nutrient supply • Cognition & emotions

  7. Feed-back

  8. Biochemistry of hormones

  9. Protein hormones

  10. Steroid hormones

  11. Transport of hormones • Soluble • Bound to proteins • SHBG, CBG, ... • Albumin • Free „biologically active“ fraction • Receptors for binding globulins • Plasma half-life • Highly variable

  12. Hormone receptors • Membrane-bound receptors • G-protein coupled receptors • Serine/threonine kinases • Tyrosine kinases • Ion channels • Intracellular receptors • Steroid nuclear receptors

  13. Hormone receptors

  14. G-protein coupled receptors

  15. Receptor kinases

  16. Protein vs. steroid receptors

  17. Steroid receptors

  18. Steroid receptors

  19. Steroid receptors

  20. Neuroimmunoendocrinology

  21. Endocrine disorders • Overproduction • Deficiency • Resistance • Explained by physiologial mechanisms

  22. Biorhythms • Circadian • Ultradian • Infradian • Circannual • Circaseptadian • Circalunar

  23. Discussion • Journalinfo, authorinfo? • Aim? • Objects? • Methods? • Main results? • Limitations? • Application? • Conclusions?