1 / 8

Michael Jerosch-Herold, PhD Associate Professor of Radiology

MRI-Based Assessment of Neovasculariation in Carotid Plaque – A Novel Risk Marker for Plaque Rupture. Michael Jerosch-Herold, PhD Associate Professor of Radiology Director of Physics for the Cardiac Imaging Program Brigham & Women’s Hospital.

jana-mooney
Télécharger la présentation

Michael Jerosch-Herold, PhD Associate Professor of Radiology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MRI-Based Assessment of Neovasculariation in Carotid Plaque – A Novel Risk Marker for Plaque Rupture Michael Jerosch-Herold, PhD Associate Professor of Radiology Director of Physics for the Cardiac Imaging Program Brigham & Women’s Hospital

  2. New 3.0 T Bilateral 8-Channel Carotid Array and Head-Holder for Reynold Carotid Study Head Holder MGH Design Wiggins/Wald Reference: Hinton-Yates et al., TMRI 2007 8- Coils = pair of four 4.8 cm loops Coil mounted on a frame with head-holder consists of two curved paddles

  3. MRI Protocol for Dynamic Contrast Enhancement • T1-weighted 3D fast gradient echo • TR/TE/flip angle: 4.3/2.3 ms/ 20° • 3 mm slices • In-plane resolution: 0.7 x 0.7 mm • Time per dynamic view: 14 s • With new 8-element neck phased array the time per dynamic view is reduced to 10 s.

  4. Post-Processing Contrast-Enhancement in Carotid Wall

  5. Ktrans Parametric Map 24 20 16 Ktrans*1e3 [1/min] 12 8 4 Kinetic Modeling(Kety-Schmidt Model) Measured in vessel lumen Venous Outflow Arterial Input vb Tissue Extraction (Ktrans) • Model Parameters Determined by Optimization at Pixel Level • vb vascular volume • Ktrans First order blood-to-tissue transfer rate constant

  6. Ktrans Parametric Map 24 20 16 Ktrans*1e3 [1/s] 12 8 4 Examp T2 TSE: carotid plaque

  7. Example of Test-Scan in Patient with 8-Channel Phased Array Coil

More Related