Phosphodiesterase V Inhibitors

Oct 22, 2012

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Goals:. Historical treatments for Erectile Dysfunction before the PDE5 inhibitors were discoveredGeneral overview of the three drugs currently available todayDiscuss the mechanism of actionDiscuss the use of each drug (dosing, duration of action, etc)List the side effects common and unique to al

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Phosphodiesterase V Inhibitors

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INHIBITORS

INHIBITORS. What are some examples ? What experiments show they are SPECIFIC !!! Do they always work?. INHIBITORS Used to diminish or abolish a biological activity so that conclusions can be drawn about the properties of that activities or of a process by which the activity may play a role.

511 views • 16 slides

Proton Pump Inhibitors

Life before PPIs. The history of dyspepsiaSurgery and dietVagotomy/PyloroplastySteamed fish and milk puddingsH2-receptor antagonistsTagamet

1.49k views • 9 slides

LIPID BIOSYNTHESIS INHIBITORS

Lipid Biosynthesis Inhibitors (Read Chap 16, pp 181-183; Chap 13, pp. 171-174). Acetyl CoA Carboxylase (ACCase) Inhibitors (A(1))Cyclohexanediones AryloxyphenoxypropionatesPhenylpyrazolin (Axial)Fatty Acid and Lipid Biosynthesis Inhibitors (N(8),N(10),N(26)) will be discussed with seedling gro

772 views • 52 slides

Protease Inhibitors

Protease Inhibitors. Protease Inhibitors. Amprenavir (APV) – GlaxoSmithKline, 1999 1,200mg 1x/day, rare side effects: Stevens-Johnsons Synd More rare side effects: diabetes, increased cholesterol levels Side effects: vomiting, perioral parethesias, diarrhea Indinavir (IDV) – Merck, 1996

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Phosphodiesterase inhibitors

Phosphodiesterase inhibitors. By Nashwa Naeem Elfar Ass. lecturer. Phosphodiesterase enzymes (PDE).

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ACE Inhibitors

ACE Inhibitors. ACE = Angiotensin I Converting Enzyme 10 ACE inhibitors available in US: benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril and trandolapril.

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Factor Inhibitors: Cases

Factor Inhibitors: Cases. Lisa N Boggio, MS, MD Rush University Medical Center. Case 1. 12-year-old patient with severe FVIII deficiency and inhibitor Normally treats bleeds with rFVIIa ~100 µg/kg Develops pain in arm. Case 1. Case 1. Case 1: Treatment.

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Beta- Lactamase Inhibitors

Beta- Lactamase Inhibitors. Clavulanic acid, Tazobactam , Sulbactam Drug Class: inhibitors of beta- lactamase Trade Names: Augmentin ® (Amoxicillin + Clavulanate ) Zosyn ® ( Piperacillin + Tazobactam ) Timentin ® ( Ticarcillin + Clavulanate ) Mechanism of Action:

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Allosteric Inhibitors

Allosteric Inhibitors. By Kelsey Martin and Christine Bondira. A noncompetitive inhibitor binds to the enzyme away from the active site, altering the conformation of the enzyme so that its active site no longer functions . Noncompetitive inhibitor. He took my spot!!.

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Phosphodiesterase Inhibitors

Phosphodiesterase Inhibitors. Bipyridines :( Amrinone , Milrinone ) only available in parenteral form. Half-life 3-6hrs. Excreted in urine. Mechanism of action. Inhibit phosphodiesterase isozyme 3 in cardiac & smooth muscles → : ↑ cAMP

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Inhibitors

Inhibitors. Why they happen What are they How to control them Treatment options. Why Inhibitors H appen. Genetics Hemophilia severity More common in severe hemophilia FVIII mutations Mutations in intron 22 and 1 (regions inside a gene) Nonsense mutations Stop codon

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Noncompetitive Inhibitors

Noncompetitive Inhibitors. John Simila Mary- Cate Welsh Brian Decorte. What are Noncompetitive Inhibitors?. A substance that interacts with the enzyme but not at the active site. They do not directly compete with the substrate to bind at the active site.

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Acetylcholinesterase Inhibitors

PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Acetylcholinesterase Inhibitors. By: Rohini Bagchi , Janice Chan, John Chen, Melissa Taylor Date : December 4, 2013. Overview . Background Effects of AchE Inhibitors “Good” AChE Inhibitors “Bad” AChE Inhibitors. Background.

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ACE Inhibitors

ACE Inhibitors. Charley Bruce. Plan. Indications Mechanism of action Side Effects Contraindications Metabolism Pharmacokinetics. Indications. Hypertension Heart Failure Diabetic Nephropathy Prophylaxis of Cardiovascular Events. Renin-Angiotensin-Aldosterone System. Hypertension.

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ACE Inhibitors

ACE Inhibitors. By Jessica Davies. What are ACE Inhibitors?. Angiotensin Converting Enzyme Inhibitors Used to help control Hypertension Also they help with heart failure, preventing strokes, and preventing kidney damage in people with hypertension or diabetes.

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Cholinesterase inhibitors

Cholinesterase inhibitors. R1 이영석. Cholinergic agonist. Direct acting acetylcholine, methacholine, bethanechol, carbachol Indirect acting (reversible) neostigmine, edrophonium pyridostigmine, physostigmine Indirect acting (irreversible)

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Acetylcholinesterase Inhibitors

Acetylcholinesterase Inhibitors. Acetylcholinesterase Located in synapses Substrate selectivity: ACH. Plasma cholinesterase Located in plasma (non-neuronal) Substrate selectivity: ACH Succinylcholine Local anesthetics (procaine). Types of cholinesterases. Glu 327. His 440.

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Phosphodiesterase V Inhibitors

Phosphodiesterase V Inhibitors. By Lydia Zou lzou@u.washington.edu Doctor of Pharmacy Candidate Class of 2008. Goals:. Historical treatments for Erectile Dysfunction before the PDE5 inhibitors were discovered General overview of the three drugs currently available today

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Platelet Aggregation Inhibitors

Platelet Aggregation Inhibitors. Professor. Dr. MAHMOUD KHATTAB,. The components of a platelet. Platelets and the Mechanisms of Arterial Thrombosis. Platelet adhesion and aggregation occur at the site of plaque rupture at luminal exposed subendothelium

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Phosphodiesterase Enzyme Inhibitors Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2024

Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in regulating intracellular levels of secondary messengers - cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. These enzymes identified to be pharmacologically active in the 1950s, hydrolyses cyclic nucleotides to treat various diseases such as cardiovascular, respiratory and erectile dysfunction. Distinct distribution of all the types of isoenzymes has provided possibilities for selective target therapies. Request Sample Copy of the Business Report: https://www.coherentmarketinsights.com/insight/request-sample/172

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Phosphodiesterase Enzyme Inhibitors Market: Global Industry Trend Analysis to 2026

Phosphodiesterase are a diverse family of enzymes (11 isoenzymes) that play a key role in regulating intracellular levels of secondary messengers.

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Protein Synthesis Inhibitors

Protein Synthesis Inhibitors. Tetracyclines Macrolides Chloramphenicol Aminoglycosides Clindamycin Streptogramins. Alan M. Reynared, Ph.D. QUICK REVIEW - Protein Synthesis. Tetracyclines - Structure. Excretion R 1 R 2 R 3 R 4 mg/hr

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