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Advancements in Animal Health Modeling and Simulation: Insights from AHM&S 2013 Workshop

The Animal Health Modeling & Simulation Society (AHM&S), founded in 2012, focuses on promoting the use of modeling and simulation in veterinary pharmacology and toxicology. In a half-day workshop at PAGE 2013 in Glasgow, experts discussed key topics including population pharmacokinetics, antimicrobial dosage optimization, and the influence of biological factors on drug efficacy in animals. Presentations highlighted innovative modeling applications, challenges in drug development, and strategies for managing animal health based on simulation outcomes, paving the way for improved practices in veterinary medicine.

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Advancements in Animal Health Modeling and Simulation: Insights from AHM&S 2013 Workshop

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  1. Modeling and Simulation: Animal health experience PAGE 2013 Glasgow UK Jonathan Mochel, Novartis Advanced Quantitative Sciences

  2. Workshop Animal Health Modeling & Simulation Society The Animal Health Modeling & Simulation Society (AHM&S) is a newly founded association (2012) that aims at promoting the development, application, and disseminationof modeling and simulation techniques in the field of Veterinary Pharmacology and Toxicology The association is co-chaired by Pr. Johan Gabrielsson (Europe) and Pr. Jim Riviere (USA), and currently consists of core members from both academia and industry Half-a-day workshop with presentation of modeling applications in the animal health field: • Methodological challenges with population PK in osteoarthritic dogs • Optimizing antimicrobial dosage regimens with mechanistic PK/PD modeling • Role of BSA and Hyperthermia on Carboplatin Dosing in Dogs • M&S: A Comprehensive Tool To Streamline Drug Development • Animal Health Regulatory Science Innovation Initiative (AHRSII) 2 | Peers Forum| J. Mochel | AHM&S PAGE 2013

  3. Main conference AH session: PAGE plenum • Food safety: intersection of pharmacometrics and veterinary medicine (Pr. J Riviere) • Presentation of physiological-based pharmacokinetics differences between species • Inherent sources of variability for collective therapy (e.g. dose most often unknown) • The application of population modeling to the calculation of residual levels and WT • Two models for the control of sea lice infections using chemical treatments and biological control on farmed salmon populations (Pr. G Gettinby) • Model-based approaches for capturing the infestation level of parasitized fishes • Population Model integrates biological stages of the parasite and drug effect (but not T°) • From epidemic to elimination: density-vague transmission and the design of mass dog vaccination programs (Pr. D Haydon) • High prevalence of rabbies in developing countries (Indonesia)-child death from dog bites • Simulation-based comparisons of vaccine strategies for eradicating rabbbies 3 | Peers Forum| J. Mochel | AHM&S PAGE 2013

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