1 / 16


Cholesterol. Soňa Lichovníková a Marek Kulíšek xclichovnikova@fch.vutbr.cz xckulisek@fch.vutbr.cz. What is it?. Cholesterol is a lipid substance , it belongs to sterols and it has quite complicated molecule (several carbon rings).

Télécharger la présentation


An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.


Presentation Transcript

  1. Cholesterol Soňa Lichovníková a Marek Kulíšek xclichovnikova@fch.vutbr.cz xckulisek@fch.vutbr.cz

  2. What is it? • Cholesterol is a lipid substance, it belongs to sterols and it has quite complicated molecule (several carbon rings). • It is a basic unit of cell-walls (membranes), participates in forming of sex hormones, hormones of adrenal gland and bile acids. • Cholesterol generates vitamin D, it is important in structure of nerve cells

  3. How does it look like? • 4 carbon rings with a side chain - has 8 carbons • Belongs to steroids • Subgroup of sterols (due to OH group) • Lipid group

  4. lipids - heterogenous material group, characteristic qualities: • Insolubility in water • Solubility in organic solvents • Occcurs in all body cells, mostly in nerve tissue • Also in animal fats, not in vegetable fats

  5. Metabolism of cholesterol synthesis • about 1g/day originates by synthesis • about 0,3g/day extracted from food • Cholesterol is synthesized in : • liver, small intestine, adrenal cortex, skin, aorta • first level of metabolic pathway is acetyl-COA. Than follows more than 20 reactions

  6. Metabolism of cholesterolsecretion • Cholesterol is secreted in 2 main ways: • Conversion on bile acids • Excretions of neutral sterols by stool • Synthesis of steroid hormone from cholesterol and elimination of their degradation products by urine.

  7. In what food it is? • Product of animal metabolism meat brain egg yolk liver • It is risky to use technology which leads to heating up cholesterol with air (desiccation of milk and eggs, rendering of butter and lard – žluknutí – butter and lard turning rancid)

  8. Where can it be found in body? • free, or in form of cholesterol esters with fatty acids • Their transport is allowed in blood only in form of specific elements - lipoproteins, in which fats are bound on proteins transmiters in combination with tryglicerides.

  9. Types of lipoproteins • Lipoproteins with high density (HDL) - less cholesterol than LDL and more amount of proteins. • Lipoproteins with low density (LDL) – risky for organism, transmits much of cholesterol in blood and it more often inlay in vascular walls and it makes them thinner. • Lipoproteins with very low density (VLDL) – aren´t so important like LDL and HDL, contains quite small amount of cholesterol.

  10. Occurrence in world? • Low levels of HDL - smokers and overweight persons. • High levels of HDL – in some long-lived families. • High levels of HDL – persons with good physical shape, also moderate periodic consummation of alcohol can increase HDL. • higher occurrence of ischemic heart disease in USA and in Europe. (Czech republic - third).

  11. Diseases which are caused due to cholesterol • cholesterol stores into vessels in the form of it’s compounds – necking of vessels, ISCH, ateriosclerosis

  12. Amount of cholesterol - optimal 300 mg per day and less. Genetics and it´s role (look at our parents) • Synthesis and degradation of cholesterol is genetically predicted. • But the main influence have also outer conditions, mainly the food we eat.

  13. How to reduce cholesterol? • Lower also income of sugars and maily alcohol • medicaments: statines, fibrates and their combination

  14. Curiosities • For the first time cholesterol was isolated in 18th century from bile stones. • Another research found that this steroid alcohol occurs in all cells of human body.

  15. Curiosities • Cholesterol under microscope

  16. References • http://www.lekarna.cz/detail.php?id=122 • http://www.brnacek.cz/poradna/zivot/2.htm • http://www.faf.cuni.cz/Gerontology/nutrition/agedependence/Agedependence.asp • http://www.fitnet.cz/vyziva/ZSP02.html • http://www1.lf1.cuni.cz/~zfisar/bhap/6dalsi.htm#6_2 • http://www.pacienti.cz/hcy-PS04.htm • http://www.referaty.sk/index.php?referat=3355

More Related