Understanding Blood Clotting, Immune Response, and Infection Resistance in Human Biology
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This article explores the complex processes of blood clotting and immune responses. It discusses how blood vessels repair after damage through clot formation with the involvement of blood platelets, calcium ions, and clotting factors. It also examines the role of various immune cells, including T-helper and B-cells, in responding to pathogens. Moreover, the piece highlights the potential risks for Rh-negative mothers with Rh-positive children and compares historical trends in infectious disease mortality alongside the rise of antibiotic resistance since the 1980s.
Understanding Blood Clotting, Immune Response, and Infection Resistance in Human Biology
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Presentation Transcript
The process of blood clotting Blood vessels damaged Presence of blood platelets, Calcium ions, vitamin K, several blood clotting factors Soluble fibrinogen insoluble fibrinogen form a meshwork, and seal off the catching blood cells wound
White blood cells Physical barrier e.g. skin pathogens Chemical barrier e.g. gastric juice
Antigen presenting cells T -helper cell lymphokines T -helper cell B cell T-killer cell T-memory cell T-suppressor cell Plasma cell
Anti Rh antibody produced in mother Rh-ve mother Contact of blood at birth Her 1st Rh +ve child Her subsequent child will be acted on by the antibody
1. If the mother is Rh-ve and her first child is Rh+ve. Would the mother have problem ? 2. If the mother is Rh+ve and her first child is Rh-ve. I) Would the mother have problem ? II) Would her subsequent children have problem ?
Compare this with the blue line depicting the mortality from infections since 1900. In the first 4-5 decades of the use of antimicrobial agents, there was a dramatic fall in the mortality from infections but since the mid-80's deaths due to resistant infections is slowly increasing.
(A) (B)
PABA - a substrate required for the formation of bacterial cell wall A sulphonamide
( protonsil ) ( PABA ) The pathogenic bacteria unable to multiply