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Lack of Resensitization of Bradykinin B2 Receptors in Absence of ACE

This study examines the desensitization effect of bradykinin (BK) on B2GFP receptors in CHO/BG cells. The cells, after being stimulated with 10 µmol/L BK to induce desensitization, were subsequently treated with either 10 nmol/L or 1 µmol/L of Ang1-7, Ang1-9, or enalaprilat (EPT). The results indicated that neither the peptides nor EPT were able to resensitize B2 receptors in the absence of angiotensin-converting enzyme (ACE), revealing a critical relationship between ACE expression and receptor function.

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Lack of Resensitization of Bradykinin B2 Receptors in Absence of ACE

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  1. Figure I 5 4 3 H] AA Released EPT Ang1-7 Ang1-9 2 3 [ 1 0 BKan 1 µmol/L 1 µmol/L 1 µmol/L medium 10 nmol/L 10 nmol/L 10 nmol/L Lack of resensitization of bradykinin B­2GFP receptors in absence of ACE. CHO/BG cells were stimulated with 10 mol/L BKan to desensitize them, then stimulated with either 10 nmol/L or 1 mol/L Ang 1-7, Ang 1-9 or enalaprilat (EPT). Neither peptide nor EPT (n = 3) resensitized B2 receptors in cells, without expression of ACE.

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