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Anthelmintic Efficacy of Plant Extracts on Gastrointestinal Helminths in Goats

This study evaluated the efficacy of crude water extracts of Tephrosia vogelii and Vernonia amygdalina against gastrointestinal helminthes in goats in Uganda. Results showed considerable activity, with notable differences between treatments. Further research is recommended to explore resistance and bioactivity.

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Anthelmintic Efficacy of Plant Extracts on Gastrointestinal Helminths in Goats

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  1. Efficacy of crude water extracts of selected plants against gastrointestinal helminthes in goats in Uganda 2012Immaculate Nabukenya1, Betty Ayoo1, Rubaire-Akiiki1, Johan Höglund21Makerere University, Uganda and 2Swedish University of Agricultural Sciences, Sweden METHODS INTRODUCTION SPECIFIC OBJECTIVE • Gastrointestinal helminths especially nematodes are important endoparasites causing direct and indirect losses to goat farmers. • In Uganda, several ethnoveterinary practices including use of plants to treat helminthes in goats have been documented. • Following the farmers’ advice, we constituted crude water extracts at 65 mg/ml of Tephrosia vogelii and Vernonia amygdalina administered at 50 ml once to all 40 goats in Trial one (institutional farm). Albendazole 10% was by body weight at manufacturer’s doses. • In Trial two (individual farms), we used 115 mg/ml crude extracts; administered at 50 ml daily over three days to 20 goats per group with Albendazole 10% as control. • Fecal egg count reduction test was used to assess the efficacy with pre and post treatment egg counts at day 0, 8 and 15. To evaluate efficacy of crude water extracts of two farmer selected plants against gastrointestinal helminthes in goats from Mbarara and Rakai districts in Uganda. RESULTS • Albendazole 10% had the highest reduction in epg at 88% & 98% in Trial 1 & 2; V. amygdalina at 11 and 56%; T. vogelii at 49% & 60%. • Resistance to albendazole detected on institutional farm but not on small holder farms (88% vs 98% respectively). • Significantly different reductions were recorded for day 8 and day 15 post treatment evaluations (P=0.001) Fig. 1: Mean & 95% CI of epg in Trial 1 Fig. 2: Mean & 95% CI of epg in Trial 2 CONCLUSIONS & RECOMMENDATION • Tephrosia and Vernonia show considerable anthelmintic activity. • A dose response bio-activity observed in Trial 2 where we doubled the farmer recommended doses and treated the animals three consecutive days compared to Trial 1. • Further evaluation of albendazole resistance and anthelmintic efficacy of the two plants in vitro & in vivo Vernonia amygdalina Del Tephrosia vogelii Hook ACKNOWLEDGEMENTS • National Agricultural Research Organization, Mbarara ZARDI • Makerere University • Swedish University of Agricultural Sciences Supervisors Contact: Dr. Immaculate Nabukenya +256-772-606518 lennfaith@yahoo.com

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