1 / 9

High Fat Intake Increases Circulating Endotoxin Levels in Type 2 Diabetic Subjects

This study investigates the effect of high saturated fat meals on circulating endotoxin levels in individuals with varying metabolic states, including non-obese, obese, individuals with impaired glucose tolerance (IGT), and type 2 diabetes. Participants consumed a high-fat meal after fasting overnight, with blood samples collected before and after the meal to assess endotoxin levels. Results indicate that high-fat intake elevates circulating endotoxin levels quickly, particularly in IGT and type 2 diabetic subjects, suggesting a link between metabolic endotoxemia and high-fat diets.

kato-schultz
Télécharger la présentation

High Fat Intake Increases Circulating Endotoxin Levels in Type 2 Diabetic Subjects

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Featured Article: High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects Alison L. Harte, Ph.D., Madhusudhan C. Varma, MRCP, Gyanedra Tripathi, Ph.D., Kirsty C. McGee, Ph.D., Nasser M. Al-Daghri, Ph.D., Omar S. Al-Attas, Ph.D., Shaun Sabico, M.D., Joseph P. O’Hare, M.D., Antonio Ceriello, M.D., Ponnusamy Saravanan, Ph.D., Sudesh Kumar, M.D., Philip G. McTernan, Ph.D. Diabetes Care Volume 35: 375–382 February, 2012

  2. Study Objectives • To evaluate the changes in circulating endotoxin after a high–saturated fat meal to determine whether these effects depend on metabolic disease state. Harte A et al. Diabetes Care 2012;35:375-382

  3. Study Design • Nonobese, obese, IGT, or type 2 diabetes participants were given a high-fat meal after an overnight fast • Blood was collected before (0 h) and after the meal (1–4 h) for analysis of endotoxin levels Harte A et al. Diabetes Care 2012;35:375-382

  4. Harte A et al. Diabetes Care 2012;35:375-382

  5. Harte A et al. Diabetes Care 2012;35:375-382

  6. Harte A et al. Diabetes Care 2012;35:375-382

  7. Harte A et al. Diabetes Care 2012;35:375-382

  8. Harte A et al. Diabetes Care 2012;35:375-382

  9. Conclusion • Exposure to a high-fat meal elevates circulating endotoxin irrespective of metabolic state, as early as 1 h after a meal. • However, this increase is substantial in IGT and type 2 diabetic subjects, suggesting that metabolic endotoxinemia is exacerbated after high fat intake Harte A et al. Diabetes Care 2012;35:375-382

More Related