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Mycology Review

Mycology Review. Dr. David Engman. Mycoses: Fungal Diseases. Chronic, Relapsing Rarely Contagious Cell-Mediated Immunity Delayed-Type Hypersensitivity Tissue Tropism. Differences Between Fungi and Bacteria. Size (Yeast > 5 m m, Bacteria < 2 m m) Mode of Reproduction Cell Structure

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Mycology Review

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  1. Mycology Review Dr. David Engman

  2. Mycoses: Fungal Diseases • Chronic, Relapsing • Rarely Contagious • Cell-Mediated Immunity • Delayed-Type Hypersensitivity • Tissue Tropism

  3. Differences Between Fungi and Bacteria • Size (Yeast > 5 mm, Bacteria < 2 mm) • Mode of Reproduction • Cell Structure • nucleus • mitochondrion • endoplasmic reticulum • rigid cell wall (chitin vs murein) • polysaccharides (mannan, glucan) vs LPS

  4. Mycology Basics • Yeasts vs. Molds • Dimorphism • Treatment • microtubules • membranes (sterols) • Diagnosis • Saboraud’s Agar • KOH • Dimorphism • Deuteromycetes (Fungi Imperfecta)

  5. Yeast Forms

  6. Mold Forms

  7. Superficial Fungal Infections • Tinea Capitis • Tinea Corporis • Tinea Cruris • Tinea Pedis • Tinea Unguium

  8. Superficial Fungal Infections

  9. Superficial Fungal Infections

  10. Superficial Fungal Infections

  11. Superficial Fungal Infections

  12. Superficial Fungal Infections

  13. Subcutaneous Fungal Infections • Sporotrichosis • Chromoblastomycosis • Mycetoma

  14. Subcutaneous Fungal Infections

  15. Subcutaneous Fungal Infections

  16. Subcutaneous Fungal Infections

  17. Subcutaneous Fungal Infections

  18. Subcutaneous Fungal Infections

  19. Subcutaneous Fungal Infections

  20. Systemic Fungal Infections • Histoplasmosis • Blastomycosis • Coccidioidomyocosis • Paracoccidioidomycosis • All are dimorphic

  21. Histoplasmosis • Ohio and Mississippi River Valleys • Primary Pulmonary Infection • Grow Within Pulmonary Macrophages • TB-like Lesions

  22. Histoplasmosis

  23. Blastomycosis • Midwest and Eastern North America • Similar to Histo, but not in Macrophage • Pneumonia: Fungus Ball • Broad-Based Budding

  24. Blastomycosis

  25. Blastomycosis

  26. Coccidioidomycosis • Southwest United States • Usually Self-Limiting

  27. Coccidioidomycosis

  28. Coccidioidomycosis

  29. Paracoccidioidomycosis • South American Blastomycosis • Chronic Mucocutaneous Ulcers • Women Resistant - Estrogen Inhibits

  30. Paracoccidioidomycosis

  31. Opportunistic Fungal Infections • Cryptococcosis • Aspergillosis • Zygomycosis/Mucormycosis • Candidiasis

  32. Cryptococcosis • Soil Contaminated with Pigeon Droppings • Encapsulated - Not Phagocytosed • Meningitis - Death • India Ink, Latex Agglutination, Brain Biopsy

  33. Cryptococcosis

  34. Aspergillosis • Branching Hyphae Seen on Silver Stain • Common Nosocomial in Immunocompromised

  35. Aspergillosis

  36. Mucormycosis • Absidia, Rhizopus, Mucor spp. • Diabetic Acidosis • Pulmonary or Rhinocerebral Disease • GI Disease in AIDS • Culture/Diagnosis Difficult

  37. Mucormycosis

  38. Candidiasis • Most Common Systemic Fungal Pathogen • Oral Thrush • Esophageal, Vaginal Infection Common • Colonization/Growth on Moist Skin • Germ Tube Test

  39. Candidiasis

  40. Candidiasis

  41. Candidiasis

  42. Fungal Word Association • Asteroid bodies – • Broad-based budding – • Copper sclerotic bodies – • Diabetic Ketoacidosis – • Germ Tube Test – • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  43. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – • Copper sclerotic bodies – • Diabetic Ketoacidosis – • Germ Tube Test – • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  44. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – • Diabetic Ketoacidosis – • Germ Tube Test – • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  45. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – • Germ Tube Test – • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  46. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – Mucor • Germ Tube Test – • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  47. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – Mucor • Germ Tube Test – Candida • Granulomata – • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  48. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – Mucor • Germ Tube Test – Candida • Granulomata – Histo (also Schisto, TB) • Oral Thrush – • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  49. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – Mucor • Germ Tube Test – Candida • Granulomata – Histo (also Schisto, TB) • Oral Thrush – Candida • Pigeon Droppings – • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

  50. Fungal Word Association • Asteroid bodies – Sporothrix • Broad-based budding – Blasto • Copper sclerotic bodies – Chromo • Diabetic Ketoacidosis – Mucor • Germ Tube Test – Candida • Granulomata – Histo (also Schisto, TB) • Oral Thrush – Candida • Pigeon Droppings – Crypto • Rose handler’s disease – • Southwest United States – • Wood’s lamp –

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