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Proteomic Analysis Reveals Nucleolar and Nuclear Protein Expression Changes

Study identified significant downregulation of various proteins in nuclear and nucleolar fractions, suggesting potential roles in cellular processes. The findings shed light on regulatory mechanisms and protein functions within these cellular compartments.

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Proteomic Analysis Reveals Nucleolar and Nuclear Protein Expression Changes

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  1. IPI00184848.4: ILLLDEATSALDTESEK, DCP02, ABCB11 Down 2.0-fold in nuclear fraction

  2. IPI00184848.4: ILLLDEATSALDTESEK, DCP03, ABCB11 Down 2.0-fold in nuclear fraction

  3. IPI00184848.4: ILLLDEATSALDTESEK, DCP05, ABCB11 Down 2.0-fold in nuclear fraction

  4. IPI00184848.4: ILLLDEATSALDTESEK, DCP06, ABCB11 Down 2.0-fold in nuclear fraction

  5. IPI00217466.3: VAGAATPKK, DCP03, Histone H1c Down 4.5-fold in nuclear fraction

  6. IPI00217466.3: VAGAATPKK, DCP05, Histone H1cDown 4.5-fold in nuclear fraction

  7. IPI00217466.3: VAGAATPKK, DCP06, Histone H1c Down 4.5-fold in nuclear fraction

  8. IPI00003269.1: VAPDEHPILLTEAPLNPK, DCP04, Kappa-Actin Down 2.5-fold in nuclear fraction

  9. IPI00003269.1: VAPDEHPILLTEAPLNPK, DCP07, Kappa-ActinDown 2.5-fold in nuclear fraction

  10. IPI00219301.7: AEDGATPSPSNETPK, DCP05, MARCKSDown 2.9-fold in nuclear fraction

  11. IPI00219301.7: AEDGATPSPSNETPK, DCP07, MARCKSDown 2.9-fold in nuclear fraction

  12. IPI00219301.7: AEDGATPSPSNETPK, DCP08, MARCKSDown 2.9-fold in nuclear fraction

  13. IPI00219757.13: YISLIYTNYEAGKDDYVK, DCP09, GSTP1-1 Down 2.0-fold in nuclear fraction

  14. IPI00219219.3: FNAHGDANTIVCNSK, DCP10, Galectin-1Down 3.1-fold in nuclear fraction

  15. IPI00182540: ALSAIADLLTNEHER, PA03, Catenin delta-1Down 2.3-fold in nucleolar fraction

  16. IPI00163505: VLGVPIIVQASQAEK, PA05, RBM39Up 2.0-fold in nucleolar fraction

  17. IPI00328987: HAPLADQILAGNAVR, PA06, BystinDown 2.3-fold in nucleolar fraction

  18. IPI00555744: LVAIVDVIDQNR, PA08, RPL14Up 2.0-fold in nucleolar fraction

  19. IPI00555744: LVAIVDVIDQNR, PA09, RPL14 Up 2.0-fold in nucleolar fraction

  20. IPI00024662: WKDTDEADLVLAK, PA08, CBX5 Down 2.2-fold in nucleolar fraction

  21. IPI00178440: SPAGLQVLNDYLADK, PA08, EF-1-beta, Down 2.3-fold in nucleolar fraction

  22. IPI00646899: FNADEFEDMVAEKR, PA08, RPL10 Up 2.1-fold in nucleolar fraction

  23. IPI00646899: FNADEFEDMVAEKR, PA09, RPL10Up 2.1-fold in nucleolar fraction

  24. IPI00328840: SLGTADVHFER, PA09, AlyUp 6.5-fold in nucleolar fraction

  25. IPI00221222: GISLNPEQWSQLK, PA10, PC4 Up 2.0-fold in nucleolar fraction

  26. IPI00290204: MWDPHNDPNAQGDAFK, DCP05, U1 snRNP 70 Up 2.36-fold in nucleolar fraction

  27. IPI00012066: ESTGAQVQVAGDMLPNSTER, PCBP2Up 2.95-fold in the nucleolar fraction (continued on next slide)

  28. IPI00012066: ESTGAQVQVAGDMLPNSTER, PCBP2Up 2.95-fold in the nucleolar fraction (continued) Monoisotopic mass of neutral peptide Mr(calc): 2088.974594Fixed modifications: Carbamidomethyl (C)Ions Score: 53 Expect: 0.00044 Matches (Bold Red): 19/208 fragment ions using 45 most intense peaks

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