1 / 8

Cell Growth Pathway Analysis Tool

Interactive tool detailing cell growth pathways from early G1 to late G1 phase, covering mitogenic signals, DNA repair, senescence, apoptosis, and key regulatory factors. Explore and understand cellular processes.

kreeli
Télécharger la présentation

Cell Growth Pathway Analysis Tool

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Early-Mid G1 Restriction Pt. Late G1 S All pathways Click to continue Mitogenic signals  Ras DNA Repair DNA Damage BRCA2 Senescence / Apoptosis Red = inhibits cell growth Line = inhibits next step mdm2 ATM CDK2 Cyclin A myc Click on any yellow box Click on any yellow box Click on any yellow box BCL-2 PKB Arrow = leads to next step DNA Replication Bax CDK4/6 Cyclin D Return to main page End show Go to next pathway Previous pathway p53 Green = increases cell growth TGF-β p16INK4 p14ARF p21 TGF-β myc CDK2 Cyclin E p27 Master Switch Rb E2F E2F DNA Replication Factors

  2. Early-Mid G1 Restriction Pt. Late G1 S All pathways Mitogenic signals  Ras DNA Repair DNA Damage BRCA2 Senescence / Apoptosis mdm2 ATM CDK2 Cyclin A myc BCL-2 PKB DNA Replication Bax CDK4/6 Cyclin D p53 TGF-β p16INK4 p14ARF p21 TGF-β myc CDK2 Cyclin E p27 Master Switch Rb E2F E2F DNA Replication Factors

  3. Early-Mid G1 Restriction Pt. Late G1 S Mitogen Mitogenic signals  Ras CDK2 Cyclin A myc DNA Replication CDK4/6 Cyclin D CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  4. Early-Mid G1 Restriction Pt. Late G1 S myc DNA Repair Senescence / Apoptosis CDK2 Cyclin A myc BCL-2 DNA Replication Bax CDK4/6 Cyclin D p53 p16INK4 p14ARF p21 myc CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  5. Early-Mid G1 Restriction Pt. Late G1 S Master Switch CDK2 Cyclin A DNA Replication CDK2 Cyclin E Master Switch Rb E2F E2F DNA Replication Factors

  6. Early-Mid G1 Restriction Pt. Late G1 S DNA damage DNA Repair DNA Damage BRCA2 Senescence / Apoptosis mdm2 ATM BCL-2 Bax p53 p21 CDK2 Cyclin E

  7. Early-Mid G1 Restriction Pt. Late G1 S PKB DNA Repair Senescence / Apoptosis BCL-2 PKB Bax p53 p21 CDK2 Cyclin E p27

  8. Early-Mid G1 Restriction Pt. Late G1 S TGF-β Senescence / Apoptosis TGF-β p16INK4 TGF-β CDK2 Cyclin E p27

More Related